Diversification of the Primary Antibody Repertoire by AID-Mediated Gene Conversion Journal Article


Authors: Lanning, D. K.; Knight, K. L.
Article Title: Diversification of the Primary Antibody Repertoire by AID-Mediated Gene Conversion
Abstract: Gene conversion, mediated by activation-induced cytidine deaminase (AID), has been found to contribute to generation of the primary antibody repertoire in several vertebrate species. Generation of the primary antibody repertoire by gene conversion of immunoglobulin (Ig) genes occurs primarily in gut-associated lymphoid tissues (GALT) and is best described in chicken and rabbit. Here, we discuss current knowledge of the mechanism of gene conversion as well as the contribution of the microbiota in promoting gene conversion of Ig genes. Finally, we propose that the antibody diversification strategy used in GALT species, such as chicken and rabbit, is conserved in a subset of human and mouse B cells.
Journal Title: Results and problems in cell differentiation
Volume: 57
ISSN: 0080-1844; 0080-1844
Publisher: Unknown  
Journal Place: Germany
Date Published: 2015
Start Page: 279
End Page: 293
Language: eng
DOI/URL:
Notes: JID: 0173555; ppublish