The remnant of the European rabbit (Oryctolagus cuniculus) IgD gene Journal Article

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Authors: Lanning, D. K.; Esteves, P. J.; Knight, K. L.
Article Title: The remnant of the European rabbit (Oryctolagus cuniculus) IgD gene
Abstract: Although IgD first appeared, along with IgM, in the cartilaginous fishes and has been retained throughout subsequent vertebrate evolution, it has been lost in a diverse group of vertebrate species. We previously showed that, unlike vertebrates that express IgD, the rabbit lacks an IgD (Cdelta) gene within 13.5 kb downstream of the IgM gene. We report here that, by conducting BLAST searches of rabbit Ig heavy chain genomic DNA with known mammalian IgD exons, we identified the remnant of the rabbit Cdelta gene approximately 21 kb downstream of the IgM gene. The remnant Cdelta locus lacks the deltaCH1 and hinge exons, but contains truncated deltaCH2 and deltaCH3 exons, as well as largely intact, but non-functional, secretory and transmembrane exons. In addition, we report that the Cdelta gene probably became non-functional in leporids at least prior to the divergence of rabbits and hares ~12 million years ago.
Journal Title: PloS one
Volume: 12
Issue: 8
ISSN: 1932-6203; 1932-6203
Publisher: Unknown  
Journal Place: United States
Date Published: 2017
Start Page: e0182029
Language: eng
DOI/URL:

10.1371/journal.pone.0182029
Notes: LR: 20171207; GR: R01 AI050260/AI/NIAID NIH HHS/United States; JID: 101285081; 0 (Immunoglobulin D); 2017/01/08 00:00 [received]; 2017/07/11 00:00 [accepted]; 2017/08/24 06:00 [entrez]; 2017/08/24 06:00 [pubmed]; 2017/10/20 06:00 [medline]; epublish