Cutting Edge: AhR Is a Molecular Target of Calcitriol in Human T Cells Journal Article

Authors: Takami, M; Fujimaki, K.; Nishimura, M. I.; Iwashima, M
Article Title: Cutting Edge: AhR Is a Molecular Target of Calcitriol in Human T Cells
Abstract: The immunoregulatory functions of vitamin D have been well documented in various immunological disorders, including multiple sclerosis, arthritis, and asthma. IL-10 is considered a chief effector molecule that promotes the vitamin D-induced immunosuppressive states of T cells and accessory cells. In this article, we demonstrate that the active form of vitamin D, 1,25-dihydroxyvitamin D3 (calcitriol), has a profound inhibitory effect on the development of human Th9, a CD4 T cell subset that is highly associated with asthma, in an IL-10-independent manner. Our data show that calcitriol represses the expression of BATF, a transcription factor essential for Th9, via suppressing the expression of aryl hydrocarbon receptor, without an increase in IL-10. The data show a novel link between vitamin D and two key transcription factors involved in T cell differentiation.
Journal Title: Journal of immunology (Baltimore, Md.: 1950)
Volume: 195
Issue: 6
ISSN: 1550-6606; 0022-1767
Publisher: by The American Association of Immunologists, Inc  
Date Published: 2015
Start Page: 2520
End Page: 2523
Language: ENG
Notes: LR: 20150816; CI: Copyright (c) 2015; JID: 2985117R; aheadofprint