Malignant acrospiroma: a case report in the era of next generation sequencing Journal Article

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Authors: Diab, M.; Gabali, A.; Kittaneh, M
Article Title: Malignant acrospiroma: a case report in the era of next generation sequencing
Abstract: BACKGROUND: Malignant acrospiroma is a rare tumor of the eccrine sweat glands accounting for around 6% of all malignant eccrine tumors. Typically, it presents as large ulcerated nodules, and diagnosis can be challenging as it has great overlap with its benign counterpart. CASE PRESENTATION: We herein report a case of acral malignant acrospiroma, initially treated with surgical excision and adjuvant radiotherapy. After metastatic disease was confirmed, subject received multiple lines of chemo- as well as targeted therapy. Genomic testing was also done using next generation sequencing. CONCLUSION: To the best of our knowledge, this is the first case of acral malignant acrospiroma with reported next generation sequencing results.
Journal Title: BMC cancer
Volume: 17
Issue: 1
ISSN: 1471-2407; 1471-2407
Publisher: Unknown  
Journal Place: England
Date Published: 2017
Start Page: 221
End Page: 017-3217-5
Language: eng
DOI/URL:

10.1186/s12885-017-3217-5
Notes: LR: 20170403; JID: 100967800; OTO: NOTNLM; 2016/02/21 [received]; 2017/03/22 [accepted]; epublish