Authors: |
Diab, M.; Gabali, A.; Kittaneh, M |
Article Title: |
Malignant acrospiroma: a case report in the era of next generation sequencing |
Abstract: |
BACKGROUND: Malignant acrospiroma is a rare tumor of the eccrine sweat glands accounting for around 6% of all malignant eccrine tumors. Typically, it presents as large ulcerated nodules, and diagnosis can be challenging as it has great overlap with its benign counterpart. CASE PRESENTATION: We herein report a case of acral malignant acrospiroma, initially treated with surgical excision and adjuvant radiotherapy. After metastatic disease was confirmed, subject received multiple lines of chemo- as well as targeted therapy. Genomic testing was also done using next generation sequencing. CONCLUSION: To the best of our knowledge, this is the first case of acral malignant acrospiroma with reported next generation sequencing results. |
Journal Title: |
BMC cancer
|
Volume: |
17 |
Issue: |
1 |
ISSN: |
1471-2407; 1471-2407 |
Publisher: |
Unknown
|
Journal Place: |
England |
Date Published: |
2017 |
Start Page: |
221 |
End Page: |
017-3217-5 |
Language: |
eng |
DOI/URL: |
|
Notes: |
LR: 20170403; JID: 100967800; OTO: NOTNLM; 2016/02/21 [received]; 2017/03/22 [accepted]; epublish |