Disseminated Nocardia paucivorans Infection Resembling Metastatic Disease in a Kidney Transplant Recipient. Journal Article

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Authors: Luu, T; Khalid, R; Rehman, T; Clark, NM
Article Title: Disseminated Nocardia paucivorans Infection Resembling Metastatic Disease in a Kidney Transplant Recipient.
Abstract: Recipients of solid-organ transplants (SOT) or hematopoietic stem-cell transplants are prone to various complications, including serious infections. Nocardiosis is an opportunistic bacterial infection that primarily affects the lung. It may also cause skin and soft-tissue infection, cerebral abscess, bloodstream infection, or infection involving other organs. We present a case of an immunocompromised kidney transplant recipient who experienced a prolonged history of unexplained indolent constitutional symptoms without a fever. Initial radiographic findings were suggestive of metastatic disease at multiple sites. However, metagenomic next-generation sequencing of microbial cell-free DNA in blood revealed disseminated infection, and organisms consistent with were identified on histopathology of a lung biopsy. It is crucial for healthcare providers to be aware of unusual opportunistic infections to provide appropriate workups and interventions for immunocompromised SOT recipients.
Journal Title: Cureus
ISSN: 2168-8184; 2168-8184
Publisher: Unknown  
Date Published: 2022