Remote Postconditioning Induced by Trauma Protects the Mouse Heart against Ischemia Reperfusion Injury. Involvement of the Neural Pathway and Molecular Mechanisms Journal Article

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Authors: Song, Y; Shan, J. G.; Xue, Z.; Wang, S. Y.; Xu, H.; Liu, Y; Guo, Y. S.; Ren, X
Article Title: Remote Postconditioning Induced by Trauma Protects the Mouse Heart against Ischemia Reperfusion Injury. Involvement of the Neural Pathway and Molecular Mechanisms
Abstract: PURPOSE: Abdominal superficial surgical incision elicits cardioprotection against myocardial ischemia reperfusion (I/R) injury in mice. This cardioprotective phenomenon, termed remote preconditioning of trauma (RPCT), results in an 80 to 85 % reduction in cardiac infarct size. We evaluated cardioprotection and the molecular mechanisms of remote postconditioning of trauma (RPostCT) in a murine I/R injury model. METHODS: Mice were analyzed using a previously established I/R injury model. An abdominal superficial surgical incision was made 45 min after myocardial ischemia at the end of coronary occlusion, and infarct size was determined 24 h after reperfusion. RESULTS: The results indicated that a strong cardioprotective effect occurred during RPostCT (56.94 +/- 2.71 % sham vs. 15.58 +/- 2.16 % RPostCT; the mean area of the infarct divided by the mean area of the region at risk; p
Journal Title: Cardiovascular drugs and therapy / sponsored by the International Society of Cardiovascular Pharmacotherapy
Publisher: Unknown  
Date Published: 2016