Alcohol Modulation of the Postburn Hepatic Response Journal Article

Authors: Chen, M. M.; Carter, S. R.; Curtis, B. J.; O'Halloran, E. B.; Gamelli, R. L.; Kovacs, E. J.
Article Title: Alcohol Modulation of the Postburn Hepatic Response
Abstract: The widespread and rapidly increasing trend of binge drinking is accompanied by a concomitant rise in the prevalence of trauma patients under the influence of alcohol at the time of their injury. Epidemiological evidence suggests up to half of all adult burn patients are intoxicated at the time of admission, and the presence of alcohol is an independent risk factor for death in the early stages post burn. As the major site of alcohol metabolism and toxicity, the liver is a critical determinant of postburn outcome, and experimental evidence implies an injury threshold exists beyond which burn-induced hepatic derangement is observed. Alcohol may lower this threshold for postburn hepatic damage through a variety of mechanisms including modulation of extrahepatic events, alteration of the gut-liver axis, and changes in signaling pathways. The direct and indirect effects of alcohol may prime the liver for the second-hit of many overlapping physiologic responses to burn injury. In an effort to gain a deeper understanding of how alcohol potentiates postburn hepatic damage, the authors summarize possible mechanisms by which alcohol modulates the postburn hepatic response.
Journal Title: Journal of burn care research : official publication of the American Burn Association
ISSN: 1559-0488; 1559-047X
Publisher: Unknown  
Date Published: 2015
Language: ENG
Notes: LR: 20150824; GR: F30 AA022856/AA/NIAAA NIH HHS/United States; GR: R01 AA012034/AA/NIAAA NIH HHS/United States; GR: R01 AG018859/AG/NIA NIH HHS/United States; GR: R01 GM115257/GM/NIGMS NIH HHS/United States; GR: T32 AA013527/AA/NIAAA NIH HHS/United States; GR: T32 GM008750/GM/NIGMS NIH HHS/United States; JID: 101262774; aheadofprint