Alcohol potentiates postburn remote organ damage through shifts in fluid compartments mediated by bradykinin Journal Article


Authors: Chen, M. M.; O'Halloran, E. B.; Ippolito, J. A.; Choudhry, M. A.; Kovacs, E. J.
Article Title: Alcohol potentiates postburn remote organ damage through shifts in fluid compartments mediated by bradykinin
Abstract: Of the 450,000 burn patients each year, 50% have a positive blood alcohol content, and this predisposes them to worsened clinical outcomes. Despite high prevalence and established consequences, the mechanisms responsible for alcohol-mediated complications of postburn remote organ damage are currently unknown. To this end, mice received a single dose of alcohol (1.12 g/kg) or water by oral gavage and were subjected to a 15% total body surface area burn. Animals with a burn alone lost approximately 5% of their body weight in 24 h, whereas intoxicated and burned mice lost only 1% body weight (P 0.05) despite a 17% increase in hematocrit (P 0.05) and a 57% increase in serum creatinine (P 0.05) over burn injury alone. This retention of water weight despite increased dehydration suggests that intoxication at the time of a burn causes a shift in fluid compartments that may exacerbate end-organ ischemia and damage as evidenced by a 3-fold increase in intestinal bacterial translocation (P 0.05), a 30% increase (P 0.05) in liver weight-to-body weight ratio, and an increase in alveolar wall thickness over a burn alone. Furthermore, administration of the bradykinin antagonist HOE140 30 min after intoxication and burn restored fluid balance and alleviated end-organ damage. These findings suggest that alcohol potentiates postburn remote organ damage through shifts in fluid compartments mediated by bradykinin.
Journal Title: Shock
Volume: 43
Issue: 1
ISSN: 1540-0514; 1073-2322
Publisher: Unknown  
Journal Place: United States
Date Published: 2015
Start Page: 80
End Page: 84
Language: eng
DOI/URL:
Notes: LR: 20141218; GR: F30 AA022856/AA/NIAAA NIH HHS/United States; GR: F30AA022856/AA/NIAAA NIH HHS/United States; GR: F31 AA022566/AA/NIAAA NIH HHS/United States; GR: F31 AA022566/AA/NIAAA NIH HHS/United States; GR: R01 AA012034/AA/NIAAA NIH HHS/United States; GR: R01AA012034/AA/NIAAA NIH HHS/United States; GR: T32 AA013527/AA/NIAAA NIH HHS/United States; GR: T32 GM008750/GM/NIGMS NIH HHS/United States; GR: T32AA013527/AA/NIAAA NIH HHS/United States; JID: 9421564; NIHMS626176; OID: NLM: NIHMS626176 [Available on 01/01/16]; OID: NLM: PMC4269565 [Available on 01/01/16]; PMCR: 2016/01/01 00:00; ppublish