Association of elevated serum aminotransferase levels with chronic kidney disease measures: hispanic community health study/study of latinos. Journal Article

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Authors: Missikpode, C; Kramer, H; Cotler, SJ; Durazo-Arvizu, R; Lash, JP; Kallwitz, E; Cai, J; Kuniholm, MH; Rosas, SE; Ricardo, AC; Talavera, GA; Raij, L; Pirzada, A; Daviglus, ML
Article Title: Association of elevated serum aminotransferase levels with chronic kidney disease measures: hispanic community health study/study of latinos.
Abstract: BACKGROUND: Previous studies have shown an association between non-alcoholic fatty liver disease (NAFLD) and chronic kidney disease (CKD), but it is unclear whether the association is independent of metabolic syndrome. METHODS: Data from 13,006 participants aged 18 to 74 years in the Hispanic Community Health Study/Study of Latinos (HCHS/SOL) without viral hepatitis, excessive alcohol consumption, or high transferrin saturation levels were analyzed. Suspected NAFLD was defined as presence of sex-specific elevations in serum aminotransferase levels (aspartate aminotransferase (AST)?>?37 U/L or alanine aminotransferase (ALT)?>?40 U/L for men and AST or ALT?>?31 U/L for women). Logistic regression was used to examine cross-sectional associations of elevated serum aminotransferase levels with low estimated glomerular filtration rate (eGFR?60 ml/min/1.73 m based on cystatin C), and with high urinary albumin-to-creatinine ratio (UACR) (>?17 mg/g in men and >?25 mg/ g in women) in separate models adjusting for demographic characteristics and metabolic syndrome. RESULTS: Mean (SD) age was 41 (0.27) years, and 45?% were male. Elevated serum aminotransferase levels were noted in 18.8?% of the population and were associated with greater odds of high UACR (OR?=?1.31; 95?% CI?=?1.10, 1.56) after adjusting for demographic characteristics; this association became non-significant after adjustment for metabolic syndrome (OR?=?1.11, 95?% CI?=?0.92, 1.33). In contrast, elevated serum aminotransferase levels were not associated with low eGFR (odds ratio (OR)?=?0.73; 95?% confidence interval (CI)?=?0.45, 1.18) after adjusting for covariates. CONCLUSIONS: In this sample of diverse U.S. Hispanic Latino adults, elevated serum aminotransferase levels were not independently associated with measures of CKD.
Journal Title: BMC nephrology
ISSN: 1471-2369; 1471-2369
Publisher: Unknown  
Date Published: 2021