Variants in CXADR and F2RL1 are associated with blood pressure and obesity in African-Americans in regions identified through admixture mapping Journal Article

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Authors: Shetty, P. B.; Tang, H.; Tayo, B. O.; Morrison, A. C.; Hanis, C. L.; Rao, D. C.; Young, J. H.; Fox, E. R.; Boerwinkle, E.; Cooper, R. S.; Risch, N. J.; Zhu, X.; Candidate Gene Association Resource (CARe) Consortium
Article Title: Variants in CXADR and F2RL1 are associated with blood pressure and obesity in African-Americans in regions identified through admixture mapping
Abstract: OBJECTIVE: Genetic variants in 296 genes in regions identified through admixture mapping of hypertension, BMI, and lipids were assessed for association with hypertension, blood pressure (BP), BMI, and high-density lipoprotein cholesterol (HDL-C). METHODS: This study identified coding SNPs identified from HapMap2 data that were located in genes on chromosomes 5, 6, 8, and 21, wherein ancestry association evidence for hypertension, BMI, or HDL-C was identified in previous admixture mapping studies. Genotyping was performed in 1733 unrelated African-Americans from the National Heart, Lung and Blood Institute's Family Blood Pressure Project, and gene-based association analyses were conducted for hypertension, SBP, DBP, BMI, and HDL-C. A gene score based on the number of minor alleles of each SNP in a gene was created and used for gene-based regression analyses, adjusting for age, age, sex, local marker ancestry, and BMI, as applicable. An individual's African ancestry estimated from 2507 ancestry-informative markers was also adjusted for to eliminate any confounding due to population stratification. RESULTS: CXADR (rs437470) on chromosome 21 was associated with SBP and DBP with or without adjusting for local ancestry (P 0.0006). F2RL1 (rs631465) on chromosome 5 was associated with BMI (P = 0.0005). Local ancestry in these regions was associated with the respective traits as well. CONCLUSION: This study suggests that CXADR and F2RL1 likely play important roles in BP and obesity variation, respectively; and these findings are consistent with those of other studies, so replication and functional analyses are necessary.
Keywords: Female; Humans; Male; Public Health Sciences; Polymorphism, Single Nucleotide; African Americans/genetics; Blood Pressure/genetics; Chromosomes, Human, Pair 21; Coxsackie and Adenovirus Receptor-Like Membrane Protein/genetics; Obesity/ethnology/genetics; Receptors, Thrombin/genetics
Journal Title: Journal of hypertension
Volume: 30
Issue: 10
ISSN: 1473-5598; 0263-6352
Publisher: Unknown  
Journal Place: England
Date Published: 2012
Start Page: 1970
End Page: 1976
Language: eng
DOI/URL:

10.1097/HJH.0b013e3283578c80
Notes: LR: 20131114; GR: HL086718/HL/NHLBI NIH HHS/United States; GR: R01 HL086718/HL/NHLBI NIH HHS/United States; JID: 8306882; 0 (CLMP protein, human); 0 (Coxsackie and Adenovirus Receptor-Like Membrane Protein); 0 (Receptors, Thrombin); 0 (protease-activated receptor 3); NIHMS439851; OID: NLM: NIHMS439851; OID: NLM: PMC3575678; ppublish