Variants for HDL-C, LDL-C and Triglycerides Identified from Admixture Mapping and Fine-Mapping Analysis in African-American Families Journal Article

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Authors: Candidate Gene Association Resource (CARe) Consortium; Shetty, P. B.; Tang, H; Feng, T.; Tayo, B; Morrison, A. C.; Kardia, S. L.; Hanis, C. L.; Arnett, D. K.; Hunt, S. C.; Boerwinkle, E; Rao, D. C.; Cooper, R. S.; Risch, N; Zhu, X
Article Title: Variants for HDL-C, LDL-C and Triglycerides Identified from Admixture Mapping and Fine-Mapping Analysis in African-American Families
Abstract: BACKGROUND: -Admixture mapping of lipids was followed-up by family-based association analysis to identify variants for cardiovascular disease in African-Americans. METHODS AND RESULTS: -The present study conducted admixture mapping analysis for total cholesterol, high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C) and triglycerides. The analysis was performed in 1,905 unrelated African-American subjects from the National Heart, Lung and Blood Institute's Family Blood Pressure Program. Regions showing admixture evidence were followed-up with family-based association analysis in 3,556 African-American subjects from the FBPP. The admixture mapping and family-based association analyses were adjusted for age, age2, sex, body-mass-index, and genome-wide mean ancestry to minimize the confounding due to population stratification. Regions that were suggestive of local ancestry association evidence were found on chromosomes 7 (LDL-C), 8 (HDL-C), 14 (triglycerides) and 19 (total cholesterol and triglycerides). In the fine-mapping analysis, 52,939 SNPs were tested and 11 SNPs (8 independent SNPs) showed nominal significant association with HDL-C (2 SNPs), LDL-C (4 SNPs) and triglycerides (5 SNPs). The family data was used in the fine-mapping to identify SNPs that showed novel associations with lipids and regions including genes with known associations for cardiovascular disease. CONCLUSIONS: -This study identified regions on chromosomes 7, 8, 14 and 19 and 11 SNPs from the fine-mapping analysis that were associated with HDL-C, LDL-C and triglycerides for further studies of cardiovascular disease in African-Americans.
Journal Title: Circulation.Cardiovascular genetics
Volume: 8
Issue: 1
ISSN: 1942-3268; 1942-3268
Publisher: Unknown  
Date Published: 2014
Start Page: 106
End Page: 113
Language: ENG
DOI/URL:

CIRCGENETICS.114.000481
Notes: LR: 20150109; GR: R01 HG003054/HG/NHGRI NIH HHS/United States; GR: R01 HL086718/HL/NHLBI NIH HHS/United States; GR: T32 HL007567/HL/NHLBI NIH HHS/United States; JID: 101489144; OTO: NOTNLM; aheadofprint