New device for nonvolitional evaluation of quadriceps force in ventilated patients Journal Article


Authors: Laghi, F.; Khan, N; Schnell, T.; Aleksonis, D.; Hammond, K.; Shaikh, H.; Collins, E; Jubran, A.; Tobin, M. J.
Article Title: New device for nonvolitional evaluation of quadriceps force in ventilated patients
Abstract: INTRODUCTION: In mechanically ventilated patients, nonvolitional assessment of quadriceps weakness using femoral-nerve stimulation (twitch force) while the leg rests on a right-angle trapezoid or dangles from the bed edge is impractical. Accordingly, we developed a knee-support apparatus for use in ventilated patients. METHODS: Ninety subjects (12 ventilated patients, 28 ambulatory patients, and 50 healthy subjects) were enrolled. Twitches with leg-dangling, trapezoid, and knee-support setups were compared. RESULTS: Knee-support twitches were similar to trapezoid twitches but smaller than leg-dangling twitches (P lt; 0.0001). Inter- and intraoperator agreement was high for knee-support twitches at 1 week and 1 month. In ventilated patients, knee-support twitches were smaller than in healthy subjects and ambulatory patients (P lt; 0.004). DISCUSSION: The new knee-support apparatus allows accurate recording of quadriceps twitches. The ease of use in ventilated patients and excellent inter- and intraoperator agreement suggest that this technique is suitable for cross-sectional and longitudinal studies in critically ill patients. Muscle Nerve 57: 784-791, 2018.
Journal Title: Muscle nerve
Volume: 57
Issue: 5
ISSN: 1097-4598; 0148-639X
Publisher: Wiley Periodicals, Inc  
Journal Place: United States
Date Published: 2018
Start Page: 784
End Page: 791
Language: eng
DOI/URL:
Notes: LR: 20180425; CI: (c) 2018; GR: I01 RX001325/RX/RRD VA/United States; JID: 7803146; NIHMS930675; OTO: NOTNLM; PMCR: 2019/05/01 00:00; 2017/01/31 00:00 [received]; 2017/11/16 00:00 [revised]; 2017/11/26 00:00 [accepted]; 2019/05/01 00:00 [pmc-release]; 2017/12/02 06:00 [pubmed]; 2017/12/02 06:00 [medline]; 2017/12/02 06:00 [entrez]; ppublish
LUC Authors
  1. Amal Jubran
    6 Jubran
  2. Franco Laghi
    12 Laghi
  3. Martin J. Tobin
    6 Tobin
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