Multicenter Automatic Defibrillator Implantation Trial-Subcutaneous Implantable Cardioverter Defibrillator (MADIT S-ICD): Design and clinical protocol Journal Article

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Authors: Kutyifa, V.; Beck, C.; Brown, M. W.; Cannom, D.; Daubert, J.; Estes, M.; Greenberg, H.; Goldenberg, I; Hammes, S.; Huang, D.; Klein, H; Knops, R.; Kosiborod, M.; Poole, J.; Schuger, C.; Singh, J. P.; Solomon, S.; Wilber, D; Zareba, W.; Moss, A. J.; MADIT S-ICD Executive Committee
Article Title: Multicenter Automatic Defibrillator Implantation Trial-Subcutaneous Implantable Cardioverter Defibrillator (MADIT S-ICD): Design and clinical protocol
Abstract: Patients with diabetes mellitus, prior myocardial infarction, older age, and a relatively preserved left ventricular ejection fraction remain at risk for sudden cardiac death that is potentially amenable by the subcutaneous implantable cardioverter defibrillator with a good risk-benefit profile. The launched MADIT S-ICD study is designed to test the hypothesis that post-myocardial infarction diabetes patients with relatively preserved ejection fraction of 36%-50% will have a survival benefit from a subcutaneous implantable cardioverter defibrillator.
Journal Title: American Heart Journal
Volume: 189
ISSN: 1097-6744; 0002-8703
Publisher: The Author(s). Published by Elsevier Inc  
Journal Place: United States
Date Published: 2017
Start Page: 158
End Page: 166
Language: eng
DOI/URL:

S0002-8703(17)30140-0
Notes: LR: 20170619; CI: Copyright (c) 2017; JID: 0370465; 2017/03/12 [received]; 2017/04/30 [accepted]; ppublish