Cardiac magnetic resonance for prophylactic implantable-cardioverter defibrillator therapy international study: prognostic value of cardiac magnetic resonance-derived right ventricular parameters substudy. Journal Article

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Authors: Al'Aref, SJ; Altibi, AM; Malkawi, A; Mansour, M; Baskaran, L; Masri, A; Rahmouni, H; Abete, R; Andreini, D; Aquaro, G; Barison, A; Bogaert, J; Camastra, G; Carigi, S; Carrabba, N; Casavecchia, G; Censi, S; Cicala, G; Conte, E; De Cecco, CN; De Lazzari, M; Di Giovine, G; Di Roma, M; Dobrovie, M; Focardi, M; Gaibazzi, N; Gismondi, A; Gravina, M; Guglielmo, M; Lanzillo, C; Lombardi, M; Lorenzoni, V; Lozano-Torres, J; Margonato, D; Martini, C; Marzo, F; Masci, P; Masi, A; Memeo, R; Moro, C; Mushtaq, S; Nese, A; Palumbo, A; Pavon, AG; Pedrotti, P; Pepi, M; Perazzolo Marra, M; Pica, S; Pradella, S; Presicci, C; Rabbat, MG; Raineri, C; Rodriguez-Palomares, JF; Sbarbati, S; Schoepf, UJ; Squeri, A; Sverzellati, N; Symons, R; Tat, E; Timpani, M; Todiere, G; Valentini, A; Varga-Szemes, A; Volpe, A; Fusini, L; Guaricci, AI; Schwitter, J; Pontone, G
Article Title: Cardiac magnetic resonance for prophylactic implantable-cardioverter defibrillator therapy international study: prognostic value of cardiac magnetic resonance-derived right ventricular parameters substudy.
Abstract: AIMS: Right ventricular systolic dysfunction (RVSD) is an important determinant of outcomes in heart failure (HF) cohorts. While the quantitative assessment of RV function is challenging using 2D-echocardiography, cardiac magnetic resonance (CMR) is the gold standard with its high spatial resolution and precise anatomical definition. We sought to investigate the prognostic value of CMR-derived RV systolic function in a large cohort of HF with reduced ejection fraction (HFrEF). METHODS AND RESULTS: Study cohort comprised of patients enrolled in the CarDiac MagnEtic Resonance for Primary Prevention Implantable CardioVerter DefibrillAtor ThErapy registry who had HFrEF and had simultaneous baseline CMR and echocardiography (n?=?2449). RVSD was defined as RV ejection fraction (RVEF) 45%. Kaplan-Meier curves and cox regression were used to investigate the association between RVSD and all-cause mortality (ACM). Mean age was 59.8?±?14.0 years, 42.0% were female, and mean left ventricular ejection fraction (LVEF) was 34.0?±?10.8. Median follow-up was 959 days (interquartile range: 560-1590). RVSD was present in 936 (38.2%) and was an independent predictor of ACM (adjusted hazard ratio?=?1.44; 95% CI [1.09-1.91]; P?=?0.01). On subgroup analyses, the prognostic value of RVSD was more pronounced in NYHA I/II than in NYHA III/IV, in LVEF 35% than in LVEF =35%, and in patients with renal dysfunction when compared to those with normal renal function. CONCLUSION: RV systolic dysfunction is an independent predictor of ACM in HFrEF, with a more pronounced prognostic value in select subgroups, likely reflecting the importance of RVSD in the early stages of HF progression.
Journal Title: European heart journal. Cardiovascular Imaging
Publisher: Unknown  
Date Published: 2022
LUC Authors
  1. Mark Rabbat
    88 Rabbat
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