Kcne4 deletion sex- and age-specifically impairs cardiac repolarization in mice Journal Article

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Authors: Crump, S. M.; Hu, Z.; Kant, R.; Levy, D. I.; Goldstein, S. A.; Abbott, G. W.
Article Title: Kcne4 deletion sex- and age-specifically impairs cardiac repolarization in mice
Abstract: Myocardial repolarization capacity varies with sex, age, and pathology; the molecular basis for this variation is incompletely understood. Here, we show that the transcript for KCNE4, a voltage-gated potassium (Kv) channel beta subunit associated with human atrial fibrillation, was 8-fold more highly expressed in the male left ventricle compared with females in young adult C57BL/6 mice (P 45% (P 3-fold (P = 0.01) to match noncastrated levels. KCNE4 is thereby shown to be a DHT-regulated determinant of cardiac excitability and a molecular substrate for sex- and age-dependent cardiac arrhythmogenesis.
Journal Title: FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Volume: 30
Issue: 1
ISSN: 1530-6860; 0892-6638
Publisher: Unknown  
Journal Place: United States
Date Published: 2016
Start Page: 360
End Page: 369
Language: eng
DOI/URL:

10.1096/fj.15-278754
Notes: LR: 20170220; CI: (c) FASEB.; GR: HL079275/HL/NHLBI NIH HHS/United States; GR: HL105949/HL/NHLBI NIH HHS/United States; GR: HL079275-S1/HL/NHLBI NIH HHS/United States; GR: R01 HL105949/HL/NHLBI NIH HHS/United States; GR: R01 HL079275/HL/NHLBI NIH HHS/United States; JID: 8804484; 0 (KCNE4 protein, mouse); 0 (Potassium Channels, Voltage-Gated); 3XMK78S47O (Testosterone); OID: NLM: PMC4684512 [Available on 01/01/17]; 2015/07/08 [received]; 2015/09/08 [accepted]; ppublish