Opportunistic Neurologic Infections in Patients with Acquired Immunodeficiency Syndrome (AIDS) Journal Article

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Authors: Albarillo, F.; O'Keefe, P.
Article Title: Opportunistic Neurologic Infections in Patients with Acquired Immunodeficiency Syndrome (AIDS)
Abstract: Infections of the central nervous system (CNS) in individuals with human immunodeficiency virus (HIV) remain a substantial cause of morbidity and mortality despite the introduction of highly active antiretroviral therapy (HAART) especially in the resource-limited regions of the world. Diagnosis of these infections may be challenging because findings on cerebrospinal fluid (CSF) analysis and brain imaging are nonspecific. While brain biopsy provides a definitive diagnosis, it is an invasive procedure associated with a relatively low mortality rate, thus less invasive modalities have been studied in recent years. Diagnosis, therefore, can be established based on a combination of a compatible clinical syndrome, radiologic and CSF findings, and understanding of the role of HIV in these infections. The most common CNS opportunistic infections are AIDS-defining conditions; thus, treatment of these infections in combination with HAART has greatly improved survival.
Journal Title: Current neurology and neuroscience reports
Volume: 16
Issue: 1
ISSN: 1534-6293; 1528-4042
Publisher: Unknown  
Journal Place: United States
Date Published: 2016
Start Page: 10
End Page: 015-0603-8
Language: eng
DOI/URL:

10.1007/s11910-015-0603-8
Notes: LR: 20160109; JID: 100931790; OTO: NOTNLM; ppublish