Outcomes of Burkitt lymphoma with central nervous system involvement: evidence from a large multi-center cohort study. Journal Article

Local Library Link: Find It @ Loyola

Authors: Zayac, AS; Evens, AM; Danilov, A; Smith, SD; Jagadeesh, D; Leslie, LA; Wei, C; Kim, SH; Naik, S; Sundaram, S; Reddy, N; Farooq, U; Kenkre, VP; Epperla, N; Blum, KA; Khan, N; Singh, D; Alderuccio, JP; Godara, A; Yazdy, MS; Diefenbach, C; Rabinovich, E; Varma, G; Karmali, R; Shao, Y; Trabolsi, A; Burkart, M; Martin, P; Stettner, S; Chauhan, A; Choi, YK; Straker-Edwards, A; Klein, A; Churnetski, MC; Boughan, KM; Berg, S; Haverkos, BM; Orellana-Noia, VM; D'Angelo, C; Bond, DA; Maliske, SM; Vaca, R; Magarelli, G; Sperling, A; Gordon, MJ; David, KA; Savani, M; Caimi, P; Kamdar, M; Lunning, MA; Palmisiano, N; Venugopal, P; Portell, CA; Bachanova, V; Phillips, T; Lossos, IS; Olszewski, AJ
Article Title: Outcomes of Burkitt lymphoma with central nervous system involvement: evidence from a large multi-center cohort study.
Abstract: Central nervous system (CNS) involvement in Burkitt lymphoma (BL) poses a major therapeutic challenge, and the relative ability of contemporary regimens to treat CNS involvement remains uncertain. We described prognostic significance of CNS involvement and incidence of CNS recurrence/progression after contemporary immunochemotherapy using real-world clinicopathologic data on adults with BL diagnosed between 2009 and 2018 across 30 US institutions. We examined associations between baseline CNS involvement, patient characteristics, complete response (CR) rates, and survival. We also examined risk factors for CNS recurrence. Nineteen percent (120/641) of patients (age 18-88 years) had CNS involvement. It was independently associated with HIV infection, poor performance status, involvement of =2 extranodal sites, or bone marrow involvement. First-line regimen selection was unaffected by CNS involvement (P=0.93). Patients with CNS disease had significantly lower rates of CR (59% versus 77% without; P.
Journal Title: Haematologica
ISSN: 1592-8721; 0390-6078
Publisher: Unknown  
Date Published: 2021