Non-oncogenic Acute Viral Infections Disrupt Anti-cancer Responses and Lead to Accelerated Cancer-Specific Host Death Journal Article

Local Library Link: Find It @ Loyola

Authors: Kohlhapp, F. J.; Huelsmann, E. J.; Lacek, A. T.; Schenkel, J. M.; Lusciks, J.; Broucek, J. R.; Goldufsky, J. W.; Hughes, T.; Zayas, J. P.; Dolubizno, H.; Sowell, R. T.; Kuhner, R.; Burd, S.; Kubasiak, J. C.; Nabatiyan, A.; Marshall, S.; Bommareddy, P. K.; Li, S; Newman, J. H.; Monken, C. E.; Shafikhani, S. H.; Marzo, A. L.; Guevara-Patino, J. A.; Lasfar, A.; Thomas, P. G.; Lattime, E. C.; Kaufman, H. L.; Zloza, A.
Article Title: Non-oncogenic Acute Viral Infections Disrupt Anti-cancer Responses and Lead to Accelerated Cancer-Specific Host Death
Abstract: In light of increased cancer prevalence and cancer-specific deaths in patients with infections, we investigated whether infections alter anti-tumor immune responses. We report that acute influenza infection of the lung promotes distal melanoma growth in the dermis and leads to accelerated cancer-specific host death. Furthermore, we show that during influenza infection, anti-melanoma CD8+ T cells are shunted from the tumor to the infection site, where they express high levels of the inhibitory receptor programmed cell death protein 1 (PD-1). Immunotherapy to block PD-1 reverses this loss of anti-tumor CD8+ T cells from the tumor and decreases infection-induced tumor growth. Our findings show that acute non-oncogenic infection can promote cancer growth, raising concerns regarding acute viral illness sequelae. They also suggest an unexpected role for PD-1 blockade in cancer immunotherapy and provide insight into the immune response when faced with concomitant challenges.
Journal Title: Cell reports
Volume: 17
Issue: 4
ISSN: 2211-1247
Publisher: The Author(s). Published by Elsevier Inc  
Journal Place: United States
Date Published: 2016
Start Page: 957
End Page: 965
Language: ENG
DOI/URL:

S2211-1247(16)31324-9
Notes: LR: 20161021; CI: Copyright (c) 2016; JID: 101573691; OTO: NOTNLM; 2015/11/03 [received]; 2016/01/07 [revised]; 2016/09/21 [accepted]; ppublish