Peritumoral expression of adipokines and fatty acids in breast cancer Journal Article

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Authors: Gnerlich, J.L.; Yao, K. A.; Fitchev, P. S.; Goldschmidt, R. A.; Bond, M. C.; Cornwell, M.; Crawford, S. E.
Article Title: Peritumoral expression of adipokines and fatty acids in breast cancer
Abstract: BACKGROUND: Adipokines in the tumor microenvironment may contribute to cancer growth. We hypothesized that peritumoral fat can be a source of lipid-derived energy for tumors by increasing adipose triglyceride lipase (ATGL)-mediated lipolysis and down-regulating a negative regulator of adipogenesis, pigment epithelium-derived factor (PEDF). METHODS: In a pilot study, tissue from mastectomies (n = 19) was collected from sites both adjacent (peritumoral) and distant to the tumor for comparison of ATGL, PEDF, and leptin expression levels using immunohistochemistry. Statistical analysis was performed by Student's t test to determine significance. RESULTS: Mean tumor size was 2.4 cm, and 10 (59 %) patients had tumor-positive nodes. Mean body mass index (BMI) was 28.1 kg/m(2). ATGL expression was significantly increased in obese patients (BMI >/= 30 kg/m(2)) compared with the nonobese group (P /= 2 cm had lower peritumoral stromal expression of PEDF than tumors 2 cm (P = 0.01). In node-positive cases, expression of PEDF was significantly decreased in the peritumoral stroma compared with node-negative cases (1.22 vs. 1.80, P 0.04). The leptin/PEDF ratio was markedly elevated in the peritumoral region of node-positive cases versus node-negative cases (2.17 vs. 1.18, P 0.001). CONCLUSIONS: Peritumoral expression of adipokines was altered in both obesity and more advanced breast tumors, suggesting a role for adipokines in enhancing tumor growth. Future studies should focus on the use of adipokines as biomarkers.
Journal Title: Annals of surgical oncology
Volume: 20 Suppl 3
ISSN: 1534-4681; 1068-9265
Publisher: Unknown  
Journal Place: United States
Date Published: 2013
Start Page: S731
End Page: 8
Language: eng
DOI/URL:

10.1245/s10434-013-3274-1
Notes: LR: 20151119; JID: 9420840; 0 (Adipokines); 0 (Biomarkers, Tumor); 0 (Eye Proteins); 0 (Fatty Acids); 0 (Leptin); 0 (Nerve Growth Factors); 0 (Serpins); 0 (pigment epithelium-derived factor); EC 3.1.1.3 (Lipase); EC 3.1.1.3 (PNPLA2 protein, human); 2013/02/28 [received]; 2013/09/20 [aheadofprint]; ppublish