Impact of obesity-related genes in Spanish population Journal Article

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Authors: Martinez-Garcia, F.; Mansego, M. L.; Rojo-Martinez, G.; De Marco-Solar, G.; Morcillo, S.; Soriguer, F.; Redon, J.; Pineda Alonso, M.; Martin-Escudero, J. C.; Cooper, R. S.; Chaves, F. J.
Article Title: Impact of obesity-related genes in Spanish population
Abstract: BACKGROUND: The objective was to investigate the association between BMI and single nucleotide polymorphisms previously identified of obesity-related genes in two Spanish populations. Forty SNPs in 23 obesity-related genes were evaluated in a rural population characterized by a high prevalence of obesity (869 subjects, mean age 46 yr, 62% women, 36% obese) and in an urban population (1425 subjects, mean age 54 yr, 50% women, 19% obese). Genotyping was assessed by using SNPlex and PLINK for the association analysis. RESULTS: Polymorphisms of the FTO were significantly associated with BMI, in the rural population (beta 0.87, p-value 0.001). None of the other SNPs showed significant association after Bonferroni correction in the two populations or in the pooled analysis. A weighted genetic risk score (wGRS) was constructed using the risk alleles of the Tag-SNPs with a positive Beta parameter in both populations. From the first to the fifth quintile of the score, the BMI increased 0.45 kg/m2 in Hortega and 2.0 kg/m2 in Pizarra. Overall, the obesity predictive value was low (less than 1%). CONCLUSION: The risk associated with polymorphisms is low and the overall effect on BMI or obesity prediction is minimal. A weighted genetic risk score based on genes mainly acting through central nervous system mechanisms was associated with BMI but it yields minimal clinical prediction for the obesity risk in the general population.
Keywords: Female; Humans; Male; Adult; Middle Aged; Body Mass Index; Public Health Sciences; Polymorphism, Single Nucleotide; European Continental Ancestry Group/genetics; Genotype; Adaptor Proteins, Signal Transducing/genetics; Adolescent; Aged; Alleles; Cell Adhesion Molecules, Neuronal/genetics; Diabetes Mellitus, Type 2/etiology; GPI-Linked Proteins/genetics; Linkage Disequilibrium; Nerve Tissue Proteins/genetics; Obesity/genetics; Proteins/genetics; Spain; Young Adult
Journal Title: BMC genetics
Volume: 14
ISSN: 1471-2156; 1471-2156
Publisher: Unknown  
Journal Place: England
Date Published: 2013
Start Page: 111
End Page: 2156-14-111
Language: eng
DOI/URL:

10.1186/1471-2156-14-111
Notes: JID: 100966978; 0 (Adaptor Proteins, Signal Transducing); 0 (Cell Adhesion Molecules, Neuronal); 0 (FTO protein, human); 0 (GPI-Linked Proteins); 0 (NEGR1 protein, human); 0 (Nerve Tissue Proteins); 0 (Proteins); 0 (SCA2 protein); 0 (SH2B1 protein, human); 2013/01/29 [received]; 2013/11/12 [accepted]; 2013/11/23 [aheadofprint]; epublish