Are Inflammatory Biomarkers Increased in Varicose Vein Blood? Journal Article

Authors: Lattimer, C. R.; Kalodiki, E.; Geroulakos, G.; Hoppensteadt, D; Fareed, J
Article Title: Are Inflammatory Biomarkers Increased in Varicose Vein Blood?
Abstract: OBJECTIVES: To test for the presence of inflammatory biomarkers in blood taken from varicose veins versus antecubital blood of the same patient and compare this to levels in healthy controls. METHODS: Using a multiplex biochip array method (Randox, United Kingdom), the interleukins (ILs) IL-1alpha, IL-1beta, IL-2, IL-4, IL-6, IL-8, and IL-10; vascular endothelial growth factor; interferon gamma, tumor necrosis factor alpha ; monocyte chemotactic protein 1 (MCP-1); and epidermal growth factor were measured in citrated plasma samples drawn from the arms and legs of 24 patients with varicose veins and 24 controls. RESULTS: Expressed as median (interquartile range) in pg/mL, leg samples from patients with varicose veins had significantly higher levels of IL-8 and MCP-1 compared to their own arm samples (IL-8: local 2.3 [1.71-3.3] vs systemic 2.3 [1.62-2.98], ITALIC! P = .023; MCP-1: local 114.42 [84.29-139.05] vs systemic 103.56 [79.75-126.42], ITALIC! P .0005). This was not observed in the control group. Leg samples from both patients with varicose vein and controls had higher levels of IL-6 compared to their own arm samples (patients: local 1.67 [0.82-4.48] vs systemic 1.24 [0.58-3.26], ITALIC! P = .002; controls: local 1.23 [0.83-1.7] vs systemic 1.03 [1.7-1.52], ITALIC! P = .005). No significant differences were detected with the other biomarkers. CONCLUSIONS: Blood drawn from the site of varicose veins appears to have significantly increased concentrations of IL-6, IL-8, and MCP-1 when compared to the same patient's arm blood. This supports the hypothesis that inflammation is activated from the tissues drained by the varicose veins.
Journal Title: Clinical Applied Thrombosis/Hemostasis
ISSN: 1938-2723
Publisher: Unknown  
Date Published: 2016
Language: ENG
Notes: LR: 20160423; CI: (c) The Author(s) 2016; JID: 9508125; OTO: NOTNLM; aheadofprint