Systolic blood pressure variability and lower extremity amputation in a non-elderly population with diabetes Journal Article

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Authors: Budiman-Mak, E.; Epstein, N.; Brennan, M.; Stuck, R.; Guihan, M; Huo, Z; Emanuele, N; Sohn, M. W.
Article Title: Systolic blood pressure variability and lower extremity amputation in a non-elderly population with diabetes
Abstract: OBJECTIVE: Systolic blood pressure (SBP) variability is emerging as a new risk factor for cardiovascular diseases, diabetic nephropathy, and other atherosclerotic conditions. Our objective is to examine whether it has any prognostic value for lower-extremity amputations. RESEARCH DESIGN AND METHODS: This is a nested case-control study of a cohort of patients with diabetes aged60 years and treated in the US Department of Veterans Healthcare system in 2003. They were followed over five years for any above-ankle (major) amputations. For each case with a major amputation (event), we randomly selected up to five matched controls based on age, sex, race/ethnicity, and calendar time. SBP variability was computed using three or more blood pressure measures taken during the one-year period before the event. Patients were classified into quartiles according to their SBP variability. RESULTS: The study sample included 1038 cases and 2932 controls. Compared to Quartile 1 (lowest variability), Quartile 2 had 1.4 times (OR=1.44, 95% CI=1.00-2.07) and Quartiles 3 and 4 (highest) had 2.5 times (OR for Quartile 3=2.62, 95% CI=1.85-3.72; OR for Quartile 4=2.50, 95% CI=1.74-3.59) higher risk of major amputation (P for trend0.001). This gradient relationship held in both normotensive and hypertensive groups as well as for individuals without prior peripheral vascular disease. CONCLUSIONS: This is the first study to show a significant graded relationship between SBP variability and risk of major amputation among non-elderly persons with diabetes.
Journal Title: Diabetes research and clinical practice
ISSN: 1872-8227; 0168-8227
Publisher: Unknown  
Date Published: 2016
Language: ENG
DOI/URL:

S0168-8227(16)00059-0
Notes: LR: 20160127; CI: Copyright (c) 2016; JID: 8508335; OTO: NOTNLM; 2015/04/10 [received]; 2015/10/13 [revised]; 2016/01/07 [accepted]; aheadofprint