EMT-Inducing Molecular Factors in Gynecological Cancers Journal Article

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Authors: Campo, L; Zhang, C; Breuer, E. K.
Article Title: EMT-Inducing Molecular Factors in Gynecological Cancers
Abstract: Gynecologic cancers are the unregulated growth of neoplastic cells that arise in the cervix, ovaries, fallopian tubes, uterus, vagina, and vulva. Although gynecologic cancers are characterized by different signs and symptoms, studies have shown that they share common risk factors, such as smoking, obesity, age, exposure to certain chemicals, infection with human immunodeficiency virus (HIV), and infection with human papilloma virus (HPV). Despite recent advancements in the preventative, diagnostic, and therapeutic interventions for gynecologic cancers, many patients still die as a result of metastasis and recurrence. Since mounting evidence indicates that the epithelial-mesenchymal transition (EMT) process plays an essential role in metastatic relapse of cancer, understanding the molecular aberrations responsible for the EMT and its underlying signaling should be given high priority in order to reduce cancer morbidity and mortality.
Journal Title: BioMed research international
Volume: 2015
ISSN: 2314-6141
Publisher: Unknown  
Journal Place: United States
Date Published: 2015
Start Page: 420891
Language: eng
DOI/URL:

10.1155/2015/420891
Notes: LR: 20150913; JID: 101600173; OID: NLM: PMC4556818; 2014/11/18 [received]; 2015/01/14 [accepted]; 2015/08/19 [epublish]; ppublish