TACC3 promotes epithelial-mesenchymal transition (EMT) through the activation of PI3K/Akt and ERK signaling pathways Journal Article

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Authors: Ha, G. H.; Park, J. S.; Breuer, E. K.
Article Title: TACC3 promotes epithelial-mesenchymal transition (EMT) through the activation of PI3K/Akt and ERK signaling pathways
Abstract: Transforming acidic coiled-coil protein 3 (TACC3) is a member of the TACC family, essential for mitotic spindle dynamics and centrosome integrity during mitosis. Mounting evidence suggests that deregulation of TACC3 is associated with various types of human cancer. However, the molecular mechanisms by which TACC3 contributes to the development of cancer remain largely unknown. Here, we propose a novel mechanism by which TACC3 regulates epithelial-mesenchymal transition (EMT). By modulating the expression of TACC3, we found that overexpression of TACC3 leads to changes in cell morphology, proliferation, transforming capability, migratory/invasive behavior as well as the expression of EMT-related markers. Moreover, phosphatidylinositol 3-kinase (PI3K)/Akt and extracellular signal-regulated protein kinases (ERKs) signaling pathways are critical for TACC3-mediated EMT process. Notably, depletion of TACC3 is sufficient to suppress EMT phenotype. Collectively, our findings identify TACC3 as a driver of tumorigenesis as well as an inducer of oncogenic EMT and highlight its overexpression as a potential therapeutic target for preventing EMT-associated tumor progression and invasion.
Journal Title: Cancer letters
Volume: 332
Issue: 1
ISSN: 1872-7980; 0304-3835
Publisher: Elsevier Inc  
Journal Place: Ireland
Date Published: 2013
Start Page: 63
End Page: 73
Language: eng
DOI/URL:

10.1016/j.canlet.2013.01.013

10.1016/j.canlet.2013.01.013
Notes: ID: 13060; CI: Copyright (c) 2013; JID: 7600053; 0 (CTNNB1 protein, human); 0 (Microtubule-Associated Proteins); 0 (Protein Kinase Inhibitors); 0 (TACC3 protein, human); 0 (beta Catenin); EC 2.7.1.137 (Phosphatidylinositol 3-Kinase); EC 2.7.11.1 (Proto-Oncogene Proteins c-akt); EC 2.7.11.24 (Extracellular Signal-Regulated MAP Kinases); 2012/11/02 [received]; 2013/01/04 [revised]; 2013/01/08 [accepted]; 2013/01/21 [aheadofprint]; ppublish