Transforming acidic coiled-coil proteins (TACCs) in human cancer Journal Article


Authors: Ha, G. H.; Kim, J. L.; Breuer, E. K.
Article Title: Transforming acidic coiled-coil proteins (TACCs) in human cancer
Abstract: Fine-tuned regulation of the centrosome/microtubule dynamics during mitosis is essential for faithful cell division. Thus, it is not surprising that deregulations in this dynamic network can contribute to genomic instability and tumorigenesis. Indeed, centrosome loss or amplification, spindle multipolarity and aneuploidy are often found in a majority of human malignancies, suggesting that defects in centrosome and associated microtubules may be directly or indirectly linked to cancer. Therefore, future research to identify and characterize genes required for the normal centrosome function and microtubule dynamics may help us gain insight into the complexity of cancer, and further provide new avenues for prognostic, diagnostics and therapeutic interventions. Members of the transforming acidic coiled-coil proteins (TACCs) family are emerging as important players of centrosome and microtubule-associated functions. Growing evidence indicates that TACCs are involved in the progression of certain solid tumors. Here, we will discuss our current understanding of the biological function of TACCs, their relevance to human cancer and possible implications for cancer management.
Journal Title: Cancer letters
Volume: 336
Issue: 1
ISSN: 1872-7980; 0304-3835
Publisher: Elsevier Inc  
Journal Place: Ireland
Date Published: 2013
Start Page: 24
End Page: 33
Language: eng
DOI/URL:
Notes: CI: Copyright (c) 2013; JID: 7600053; 0 (Carrier Proteins); 0 (Fetal Proteins); 0 (Microtubule-Associated Proteins); 0 (Nuclear Proteins); 0 (TACC1 protein, human); 0 (TACC2 protein, human); 0 (TACC3 protein, human); 0 (Tumor Suppressor Proteins); 2013/02/19 [received]; 2013/04/11 [revised]; 2013/04/16 [accepted]; 2013/04/23 [aheadofprint]; ppublish