SR calcium handling dysfunction, stress-response signaling pathways, and atrial fibrillation Journal Article

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Author: Ai, X
Article Title: SR calcium handling dysfunction, stress-response signaling pathways, and atrial fibrillation
Abstract: Atrial fibrillation (AF) is the most common sustained arrhythmia. It is associated with a markedly increased risk of premature death due to embolic stroke and also complicates co-existing cardiovascular diseases such as heart failure. The prevalence of AF increases dramatically with age, and aging has been shown to be an independent risk of AF. Due to an aging population in the world, a growing body of AF patients are suffering a diminished quality of life and causing an associated economic burden. However, effective pharmacologic treatments and prevention strategies are lacking due to a poor understanding of the molecular and electrophysiologic mechanisms of AF in the failing and/or aged heart. Recent studies suggest that altered atrial calcium handling contributes to the onset and maintenance of AF. Here we review the role of stress-response kinases and calcium handling dysfunction in AF genesis in the aged and failing heart.
Journal Title: Frontiers in physiology
Volume: 6
ISSN: 1664-042X; 1664-042X
Publisher: Unknown  
Journal Place: Switzerland
Date Published: 2015
Start Page: 46
Language: eng
DOI/URL:

10.3389/fphys.2015.00046
Notes: LR: 20150310; GR: R01 HL113640/HL/NHLBI NIH HHS/United States; JID: 101549006; OID: NLM: PMC4333799; OTO: NOTNLM; 2015 [ecollection]; 2014/12/02 [received]; 2015/01/30 [accepted]; 2015/02/19 [epublish]; epublish