Linkage analysis incorporating gene-age interactions identifies seven novel lipid loci: The Family Blood Pressure Program Journal Article

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Authors: Simino, J.; Kume, R.; Kraja, A. T.; Turner, S. T.; Hanis, C. L.; Sheu, W. H.; Chen, Y. D.; Jaquish, C. E.; Cooper, R. S.; Chakravarti, A; Quertermous, T.; Boerwinkle, E; Hunt, S. C.; Rao, D. C.
Article Title: Linkage analysis incorporating gene-age interactions identifies seven novel lipid loci: The Family Blood Pressure Program
Abstract: OBJECTIVE: To detect novel loci with age-dependent effects on fasting (/=8 h) levels of total cholesterol, high-density lipoprotein, low-density lipoprotein, and triglycerides using 3600 African Americans, 1283 Asians, 3218 European Americans, and 2026 Mexican Americans from the Family Blood Pressure Program (FBPP). METHODS: Within each subgroup (defined by network, race, and sex), we employed stepwise linear regression (retention p /= 3 in the meta-analysis with LOD /= 1 in at least two network and race subgroups (exclusively of non-European descent). CONCLUSION: Incorporating gene-age interactions into the analysis of lipids using multi-ethnic cohorts can enhance gene discovery. These interaction loci can guide the selection of families for sequencing studies of lipid-associated variants.
Journal Title: Atherosclerosis
Volume: 235
Issue: 1
ISSN: 1879-1484; 0021-9150
Publisher: Elsevier Inc  
Date Published: 2014
Start Page: 84
End Page: 93
Language: ENG
DOI/URL:

S0021-9150(14)00208-1
Notes: CI: Copyright (c) 2014; JID: 0242543; OTO: NOTNLM; 2014/01/06 [received]; 2014/04/07 [revised]; 2014/04/09 [accepted]; aheadofprint