Obesity paradox in amputation risk among nonelderly diabetic men. Journal Article

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Authors: Sohn, M. W.; Budiman-Mak, E.; Oh, E. H.; Park, M. S.; Stuck, R. M.; Stone, N. J.; Pearce, W. B.
Article Title: Obesity paradox in amputation risk among nonelderly diabetic men.
Abstract: The association between BMI and amputation risk is not currently well known. We used data for a cohort of diabetic patients treated in the US Department of Veterans Affairs Healthcare System in 2003. Men aged =30 kg/m(2). Individuals with BMI >=40 kg/m(2) were only half as likely to experience any (hazard ratios (HR) = 0.49; 95% confidence interval (CI), 0.30-0.80) and major amputations (HR = 0.53; 95% CI, 0.39-0.73) during follow-up as overweight individuals. While the amputation risk continued to decrease for higher BMI, amputation-free survival showed a slight upturn at BMI >40 kg/m(2). The association between obesity and amputation risk in our data shows a pattern consistent with "obesity paradox" observed in many health conditions. More research is needed to better understand pathophysiological mechanisms that may explain the paradoxical association between obesity and lower-extremity amputation (LEA) risk.
Journal Title: Obesity
Volume: 20
Issue: 2
ISSN: 1930-7381
Publisher: Unknown  
Journal Place: United States
Date Published: 2012
Start Page: 460
End Page: 462
Language: English
DOI/URL:

http://ovidsp.ovid.com/ovidweb.cgi?T=JS=Y=N=fulltext=medl=21996669

http://dx.doi.org/10.1038/oby.2011.301
Notes: ID: 12308; Record Owner: From MEDLINE, a database of the U.S. National Library of Medicine.; Status: MEDLINE; Publishing Model: Journal available in: Print-Electronic Citation processed from: Internet; NLM Journal Code: 101264860; Electronic Date of Publication: 20111013; Entry Date: 20120524