Immune suppression in the tumor microenvironment: a role for dendritic cell-mediated tolerization of T cells Journal Article

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Authors: Hurwitz, A. A.; Watkins, S. K.
Article Title: Immune suppression in the tumor microenvironment: a role for dendritic cell-mediated tolerization of T cells
Abstract: Immune suppression remains a consistent obstacle to successful anti-tumor immune responses. As tumors develop, they create a microenvironment that not only supports tumor growth and metastasis but also reduces potential adaptive immunity to tumor antigens. Among the many components of this tumor microenvironment is a population of dendritic cells which exert profound immune suppressive effects on T cells. In this review, we discuss our recent findings related to these tumor-associated dendritic cells and how targeting them may serve to generate more durable anti-tumor immune responses.
Journal Title: Cancer immunology, immunotherapy : CII
Volume: 61
Issue: 2
ISSN: 1432-0851; 0340-7004
Publisher: Unknown  
Journal Place: Germany
Date Published: 2012
Start Page: 289
End Page: 293
Language: eng
DOI/URL:

10.1007/s00262-011-1181-5

10.1007/s00262-011-1181-5
Notes: JID: 8605732; 0 (Antigens, Neoplasm); 2011/11/17 [received]; 2011/12/01 [accepted]; 2012/01/12 [aheadofprint]; ppublish