The different morphologies of urachal adenocarcinoma do not discriminate genomically by micro-RNA expression profiling Journal Article

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Authors: Bissonnette, M. L.; Kocherginsky, M; Tretiakova, M; Jimenez, R. E.; Barkan, G. A.; Mehta, V; Sirintrapun, S. J.; Steinberg, G. D.; White, K. P.; Stricker, T.; Paner, G. P.
Article Title: The different morphologies of urachal adenocarcinoma do not discriminate genomically by micro-RNA expression profiling
Abstract: Urachal adenocarcinoma has several morphologic presentations that include mucinous, enteric, signet ring cell, and not otherwise specified. Mixtures of these morphologies can occur, and percentage cut-offs are used for classification. The clinical significance of these morphologic types is currently unknown, and genetic analysis that could elucidate possible intertumoral differences has not been performed. In this study, we analyzed the micro-RNA expression profiles of 12 urachal adenocarcinomas classified using strict morphologic criteria (3 pure enteric, 3 pure mucinous, 2 signet ring cell [both 90% signet ring cell], 2 pure not otherwise specified, and 2 mixed cell types). Of 598 unique human micro-RNAs, 333 were expressed in more than 50% of the samples. Hierarchal clustering showed no distinct patterns in the genetic profiles of the morphologic types. However, there were individual micro-RNA differences when the different types were compared individually or grouped together, either by intracellular mucin production or by grouping enteric and signet ring cell together. In the later group, 13 messenger RNA species were differentially expressed (adjusted P value of
Journal Title: Human pathology
Volume: 44
Issue: 8
ISSN: 1532-8392; 0046-8177
Publisher: Elsevier Inc  
Date Published: 2013
Start Page: 1605
End Page: 1611