| Authors: |
Wood, A. R.; Esko, T; Yang, J; Vedantam, S; Pers, T. H.; Gustafsson, S.; Chu, A. Y.; Estrada, K.; Luan, J; Kutalik, Z; Amin, N; Buchkovich, M. L.; Croteau-Chonka, D. C.; Day, F. R.; Duan, Y.; Fall, T.; Fehrmann, R.; Ferreira, T.; Jackson, A. U.; Karjalainen, J.; Lo, K. S.; Locke, A. E.; Magi, R.; Mihailov, E; Porcu, E.; Randall, J. C.; Scherag, A.; Vinkhuyzen, A. A.; Westra, H. J.; Winkler, T. W.; Workalemahu, T.; Zhao, J. H.; Absher, D.; Albrecht, E.; Anderson, D; Baron, J.; Beekman, M.; Demirkan, A; Ehret, G. B.; Feenstra, B.; Feitosa, M. F.; Fischer, K; Fraser, R. M.; Goel, A; Gong, J; Justice, A. E.; Kanoni, S; Kleber, M. E.; Kristiansson, K.; Lim, U; Lotay, V; Lui, J. C.; Mangino, M; Mateo Leach, I.; Medina-Gomez, C.; Nalls, M. A.; Nyholt, D. R.; Palmer, C. D.; Pasko, D.; Pechlivanis, S.; Prokopenko, I; Ried, J. S.; Ripke, S.; Shungin, D.; Stancakova, A.; Strawbridge, R. J.; Sung, Y. J.; Tanaka, T; Teumer, A; Trompet, S; van der Laan, S. W.; van Setten, J.; Van Vliet-Ostaptchouk, J. V.; Wang, Z; Yengo, L; Zhang, W; Afzal, U; Arnlov, J.; Arscott, G. M.; Bandinelli, S; Barrett, A.; Bellis, C.; Bennett, A. J.; Berne, C.; Bluher, M.; Bolton, J. L.; Bottcher, Y.; Boyd, H. A.; Bruinenberg, M; Buckley, B. M.; Buyske, S; Caspersen, I. H.; Chines, P. S.; Clarke, R.; Claudi-Boehm, S.; Cooper, M.; Daw, E. W.; De Jong, P. A.; Deelen, J.; Delgado, G; Denny, J. C.; Dhonukshe-Rutten, R.; Dimitriou, M.; Doney, A. S.; Dorr, M.; Eklund, N.; Eury, E.; Folkersen, L.; Garcia, M. E.; Geller, F.; Giedraitis, V; Go, A. S.; Grallert, H; Grammer, T. B.; Grassler, J.; Gronberg, H.; de Groot, L. C.; Groves, C. J.; Haessler, J.; Hall, P.; Haller, T; Hallmans, G; Hannemann, A.; Hartman, C. A.; Hassinen, M; Hayward, C; Heard-Costa, N. L.; Helmer, Q.; Hemani, G.; Henders, A. K.; Hillege, H. L.; Hlatky, M. A.; Hoffmann, W.; Hoffmann, P.; Holmen, O.; Houwing-Duistermaat, J. J.; Illig, T; Isaacs, A; James, A. L.; Jeff, J.; Johansen, B.; Johansson, A; Jolley, J.; Juliusdottir, T.; Junttila, J.; Kho, A. N.; Kinnunen, L; Klopp, N.; Kocher, T.; Kratzer, W.; Lichtner, P.; Lind, L; Lindstrom, J.; Lobbens, S; Lorentzon, M; Lu, Y; Lyssenko, V.; Magnusson, P. K.; Mahajan, A; Maillard, M.; McArdle, W. L.; McKenzie, C. A.; McLachlan, S.; McLaren, P. J.; Menni, C; Merger, S.; Milani, L; Moayyeri, A.; Monda, K. L.; Morken, M. A.; Muller, G.; Muller-Nurasyid, M.; Musk, A. W.; Narisu, N; Nauck, M; Nolte, I. M.; Nothen, M. M.; Oozageer, L.; Pilz, S.; Rayner, N. W.; Renstrom, F.; Robertson, N. R.; Rose, L. M.; Roussel, R.; Sanna, S; Scharnagl, H.; Scholtens, S; Schumacher, F. R.; Schunkert, H.; Scott, R. A.; Sehmi, J.; Seufferlein, T.; Shi, J.; Silventoinen, K.; Smit, J. H.; Smith, A. V.; Smolonska, J.; Stanton, A. V.; Stirrups, K.; Stott, D. J.; Stringham, H. M.; Sundstrom, J.; Swertz, M. A.; Syvanen, A. C.; Tayo, B. O.; Thorleifsson, G; Tyrer, J. P.; van Dijk, S.; van Schoor, N. M.; van der Velde, N.; van Heemst, D; van Oort, F. V.; Vermeulen, S. H.; Verweij, N; Vonk, J. M.; Waite, L. L.; Waldenberger, M; Wennauer, R.; Wilkens, L. R.; Willenborg, C.; Wilsgaard, T.; Wojczynski, M. K.; Wong, A; Wright, A. F.; Zhang, Q.; Arveiler, D.; Bakker, S. J.; Beilby, J; Bergman, R. N.; Bergmann, S; Biffar, R; Blangero, J; Boomsma, D. I.; Bornstein, S. R.; Bovet, P; Brambilla, P.; Brown, M. J.; Campbell, H; Caulfield, M. J.; Chakravarti, A; Collins, R.; Collins, F. S.; Crawford, D. C.; Cupples, L. A.; Danesh, J; de Faire, U; den Ruijter, H. M.; Erbel, R.; Erdmann, J.; Eriksson, J. G.; Farrall, M; Ferrannini, E.; Ferrieres, J.; Ford, I; Forouhi, N. G.; Forrester, T; Gansevoort, R. T.; Gejman, P. V.; Gieger, C; Golay, A.; Gottesman, O; Gudnason, V; Gyllensten, U; Haas, D. W.; Hall, A. S.; Harris, T. B.; Hattersley, A. T.; Heath, A. C.; Hengstenberg, C.; Hicks, A. A.; Hindorff, L. A.; Hingorani, A. D.; Hofman, A; Hovingh, G. K.; Humphries, S. E.; Hunt, S. C.; Hypponen, E.; Jacobs, K. B.; Jarvelin, M. R.; Jousilahti, P.; Jula, A. M.; Kaprio, J.; Kastelein, J. J.; Kayser, M.; Kee, F.; Keinanen-Kiukaanniemi, S. M.; Kiemeney, L. A.; Kooner, J. S.; Kooperberg, C; Koskinen, S.; Kovacs, P; Kraja, A. T.; Kumari, M; Kuusisto, J; Lakka, T. A.; Langenberg, C; Le Marchand, L; Lehtimaki, T.; Lupoli, S; Madden, P. A.; Mannisto, S.; Manunta, P.; Marette, A.; Matise, T. C.; McKnight, B; Meitinger, T; Moll, F. L.; Montgomery, G. W.; Morris, A. D.; Morris, A. P.; Murray, J. C.; Nelis, M.; Ohlsson, C; Oldehinkel, A. J.; Ong, K. K.; Ouwehand, W. H.; Pasterkamp, G; Peters, A; Pramstaller, P. P.; Price, J. F.; Qi, L; Raitakari, O. T.; Rankinen, T; Rao, D. C.; Rice, T. K.; Ritchie, M.; Rudan, I; Salomaa, V; Samani, N. J.; Saramies, J.; Sarzynski, M. A.; Schwarz, P. E.; Sebert, S.; Sever, P; Shuldiner, A. R.; Sinisalo, J.; Steinthorsdottir, V.; Stolk, R. P.; Tardif, J. C.; Tonjes, A.; Tremblay, A.; Tremoli, E; Virtamo, J.; Vohl, M. C.; Electronic Medical Records and Genomics (eMERGE) Consortium; MIGen Consortium; PAGE Consortium; Lifelines Cohort Study; Amouyel, P.; Asselbergs, F. W.; Assimes, T. L.; Bochud, M; Boehm, B. O.; Boerwinkle, E; Bottinger, E. P.; Bouchard, C; Cauchi, S.; Chambers, J. C.; Chanock, S. J.; Cooper, R. S.; de Bakker, P. I.; Dedoussis, G; Ferrucci, L; Franks, P. W.; Froguel, P; Groop, L. C.; Haiman, C. A.; Hamsten, A; Hayes, M. G.; Hui, J.; Hunter, D. J.; Hveem, K; Jukema, J. W.; Kaplan, R. C.; Kivimaki, M; Kuh, D; Laakso, M; Liu, Y; Martin, N. G.; Marz, W.; Melbye, M.; Moebus, S.; Munroe, P. B.; Njolstad, I.; Oostra, B. A.; Palmer, C. N.; Pedersen, N. L.; Perola, M; Perusse, L.; Peters, U; Powell, J. E.; Power, C.; Quertermous, T.; Rauramaa, R; Reinmaa, E.; Ridker, P. M.; Rivadeneira, F; Rotter, J. I.; Saaristo, T. E.; Saleheen, D.; Schlessinger, D; Slagboom, P. E.; Snieder, H; Spector, T. D.; Strauch, K; Stumvoll, M; Tuomilehto, J; Uusitupa, M.; van der Harst, P; Volzke, H.; Walker, M.; Wareham, N. J.; Watkins, H; Wichmann, H. E.; Wilson, J. F.; Zanen, P.; Deloukas, P; Heid, I. M.; Lindgren, C. M.; Mohlke, K. L.; Speliotes, E. K.; Thorsteinsdottir, U; Barroso, I; Fox, C. S.; North, K. E.; Strachan, D. P.; Beckmann, J. S.; Berndt, S. I.; Boehnke, M; Borecki, I. B.; McCarthy, M. I.; Metspalu, A; Stefansson, K; Uitterlinden, A. G.; van Duijn, C. M.; Franke, L.; Willer, C. J.; Price, A. L.; Lettre, G; Loos, R. J.; Weedon, M. N.; Ingelsson, E; O'Connell, J. R.; Abecasis, G. R.; Chasman, D. I.; Goddard, M. E.; Visscher, P. M.; Hirschhorn, J. N.; Frayling, T. M. |
| Article Title: |
Defining the role of common variation in the genomic and biological architecture of adult human height |
| Abstract: |
Using genome-wide data from 253,288 individuals, we identified 697 variants at genome-wide significance that together explained one-fifth of the heritability for adult height. By testing different numbers of variants in independent studies, we show that the most strongly associated approximately 2,000, approximately 3,700 and approximately 9,500 SNPs explained approximately 21%, approximately 24% and approximately 29% of phenotypic variance. Furthermore, all common variants together captured 60% of heritability. The 697 variants clustered in 423 loci were enriched for genes, pathways and tissue types known to be involved in growth and together implicated genes and pathways not highlighted in earlier efforts, such as signaling by fibroblast growth factors, WNT/beta-catenin and chondroitin sulfate-related genes. We identified several genes and pathways not previously connected with human skeletal growth, including mTOR, osteoglycin and binding of hyaluronic acid. Our results indicate a genetic architecture for human height that is characterized by a very large but finite number (thousands) of causal variants. |
| Journal Title: |
Nature genetics
|
| Volume: |
46 |
| Issue: |
11 |
| ISSN: |
1546-1718; 1061-4036 |
| Publisher: |
Unknown
|
| Journal Place: |
United States |
| Date Published: |
2014 |
| Start Page: |
1173 |
| End Page: |
1186 |
| Language: |
eng |
| DOI/URL: |
|
| Notes: |
GR: CZB/4/672/Chief Scientist Office/United Kingdom; GR: P01 GM099568/GM/NIGMS NIH HHS/United States; GR: R01 GM075091/GM/NIGMS NIH HHS/United States; JID: 9216904; 2013/12/18 [received]; 2014/08/29 [accepted]; 2014/10/05 [aheadofprint]; ppublish |
