Adrenergic alpha-1 pathway is associated with hypertension among Nigerians in a pathway-focused analysis Journal Article

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Authors: Reder, N. P.; Tayo, B. O.; Salako, B; Ogunniyi, A; Adeyemo, A; Rotimi, C; Cooper, R. S.
Article Title: Adrenergic alpha-1 pathway is associated with hypertension among Nigerians in a pathway-focused analysis
Abstract: BACKGROUND: The pathway-focused association approach offers a hypothesis driven alternative to the agnostic genome-wide association study. Here we apply the pathway-focused approach to an association study of hypertension, systolic blood pressure (SBP), and diastolic blood pressure (DBP) in 1614 Nigerians with genome-wide data. METHODS AND RESULTS: Testing of 28 pathways with biological relevance to hypertension, selected a priori, containing a total of 101 unique genes and 4,349 unique single-nucleotide polymorphisms (SNPs) showed an association for the adrenergic alpha 1 (ADRA1) receptor pathway with hypertension (pp>10(-5)) SNPs offers a novel method for detecting the "missing heritability" of hypertension. These findings warrant further studies in similar and other populations to assess the generalizability of our results, and illustrate the potential of the pathway-focused approach to investigate genetic variation in hypertension.
Journal Title: PloS one
Volume: 7
Issue: 5
ISSN: 1932-6203; 1932-6203
Publisher: Unknown  
Journal Place: United States
Date Published: 2012
Start Page: e37145
Language: eng
DOI/URL:

10.1371/journal.pone.0037145
Notes: LR: 20131106; GR: R01HL053353/HL/NHLBI NIH HHS/United States; JID: 101285081; 0 (ADRA1B protein, human); 0 (Receptors, Adrenergic, alpha-1); OID: NLM: PMC3353888; 2012/02/10 [received]; 2012/04/16 [accepted]; 2012/05/16 [epublish]; ppublish