Emphasis on the Role of PF4 in the Incidence, Pathophysiology and Treatment of Heparin Induced Thrombocytopenia Journal Article


Authors: Prechel, M. M.; Walenga, J. M.
Article Title: Emphasis on the Role of PF4 in the Incidence, Pathophysiology and Treatment of Heparin Induced Thrombocytopenia
Abstract: Heparin Induced Thrombocytopenia (HIT) is caused by antibodies that recognize platelet factor 4 (PF4) associated with polyanionic glycosaminoglycan drugs or displayed on vascular cell membranes. These antibodies are elicited by multimolecular complexes that can occur when heparin is administered in clinical settings associated with abundant PF4. Heparin binding alters native PF4 and elicits immune recognition and response. While the presence of heparin is integral to immunogenesis, the HIT antibody binding site is within PF4. Thus HIT antibodies develop and function to cause thrombocytopenia and/or thrombosis only in the presence of PF4. Future emphasis on understanding the biology, turnover and regulation of PF4 may lead to insights into the prevention and treatment of HIT.
Journal Title: Thrombosis journal
Volume: 11
Issue: 1
ISSN: 1477-9560; 1477-9560
Publisher: Unknown  
Journal Place: England
Date Published: 2013
Start Page: 7
End Page: 9560-11-7
Language: eng
DOI/URL:
Notes: ID: 12931; LR: 20130419; JID: 101170542; OID: NLM: PMC3627638; 2012/12/13 [received]; 2013/03/25 [accepted]; 2013/04/05 [aheadofprint]; epublish