Modeling-Based Response-Guided Hepatitis C Treatment During Pregnancy and Postpartum. Journal Article

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Authors: Kushner, T; Nyabanga, CT; Cotler, SJ; Etzion, O; Dahari, H
Article Title: Modeling-Based Response-Guided Hepatitis C Treatment During Pregnancy and Postpartum.
Abstract: Treating hepatitis C virus (HCV) in pregnancy would address HCV during prenatal care and potentially reduce the risk of vertical transmission. Response-guided therapy could provide a means to individualize and the reduce duration of HCV treatment during pregnancy. Data from a 27-year-old woman indicated that, pretreatment, HCV was stable and that it dropped in a biphasic manner during sofosbuvir/velpatasvir therapy, reaching target not detected at time of delivery-16 days post-initiation of therapy. Mathematical modeling of measured HCV at days 0, 7, and 14 predicted that cure could have been achieved after 7 weeks of sofosbuvir/velpatasvir, reducing the duration of therapy by 5 weeks.
Journal Title: Open forum infectious diseases
ISSN: 2328-8957; 2328-8957
Publisher: Unknown  
Date Published: 2023