Genetic and environmental variation impact transferability of polygenic risk scores. Journal Article

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Authors: Araújo, DS; Wheeler, HE
Article Title: Genetic and environmental variation impact transferability of polygenic risk scores.
Abstract: Even when polygenic risk scores (PRSs) are trained in African ancestral populations, Kamiza and colleagues showed that genetic and environmental variation within sub-Saharan African populations impacts prediction performance, highlighting the challenges of clinical implementation of PRSs for risk assessment.
Journal Title: Cell reports. Medicine
Publisher: Unknown  
Date Published: 2022