Contemporary Incidence and Mortality Rates of Neuroendocrine Prostate Cancer. Journal Article

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Authors: Alanee, S; Moore, A; Nutt, M; Holland, B; Dynda, D; El-Zawahry, A; McVary, KT
Article Title: Contemporary Incidence and Mortality Rates of Neuroendocrine Prostate Cancer.
Abstract: AIM: The purpose of the study was to provide an update ever the incidence and mortality for neuroendocrine prostate cancer (NEPC) in the United States. PATIENTS AND METHODS: Using a large national database, we examined changes in age-adjusted incidence (AAIR), mortality rates (MR) and 5-year cancer-specific survival (CSS) for 378 patients diagnosed with NEPC between 1992 and 2011. Analysis was performed for all NEPC and for its two major sub-groups [small cell carcinoma (SCC) and neuroendocrine carcinoma (NEC)]. RESULTS: AAIR of NEPC continues to rise in recent years (2004-2011:+6.8%/year, p>0.05). AAIR of SCC has been increasing significantly by 6.94%/year since 2001 (from 0.470 to 0.582/1,000,000 person years, p0.05). Overall incidence-based mortality rates for NEPC did not change significantly since 1992 and similar trends were observed for SCC and NEC. CONCLUSION: The AAIR of SCC is increasing with no change in the MR of NEPC over the past 20 years.
Journal Title: Anticancer Research
ISSN: 1791-7530; 0250-7005
Publisher: Unknown  
Date Published: 2015