Intensity-Modulated Radiation Therapy Reduces Patient-Reported Chronic Toxicity Compared With Conventional Pelvic Radiation Therapy: Updated Results of a Phase III Trial. Journal Article

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Authors: Yeung, AR; Deshmukh, S; Klopp, AH; Gil, KM; Wenzel, L; Westin, SN; Konski, AA; Gaffney, DK; Small, W; Thompson, JS; Doncals, DE; Cantuaria, GHC; D'Souza, DP; Chang, A; Kundapur, V; Mohan, DS; Haas, ML; Kim, YB; Ferguson, CL; Pugh, SL; Kachnic, LA; Bruner, DW
Article Title: Intensity-Modulated Radiation Therapy Reduces Patient-Reported Chronic Toxicity Compared With Conventional Pelvic Radiation Therapy: Updated Results of a Phase III Trial.
Abstract: JCO The purpose of this update was to determine differences in patient-reported chronic toxicity and disease outcomes with intensity-modulated radiation therapy (IMRT) compared with conventional pelvic radiation. Patients with cervical and endometrial cancers who received postoperative pelvic radiation were randomly assigned to conventional radiation therapy (CRT) or IMRT. Toxicity and quality of life were assessed using Patient-Reported Outcomes version of the Common Terminology Criteria for Adverse Events, Expanded Prostate Cancer Index Composite (EPIC) bowel and urinary domains, and Functional Assessment of Cancer Therapy-General. Between 2012 and 2015, 279 eligible patients were enrolled to the study with a median follow-up of 37.8 months. There were no differences in overall survival ( = .53), disease-free survival ( = .21), or locoregional failure ( = .81). One year after RT, patients in the CRT arm experienced more high-level diarrhea frequency (5.8% IMRT 15.1% CRT, = .042) and a greater number had to take antidiarrheal medication two or more times a day (1.2% IMRT 8.6% CRT, = .036). At 3 years, women in the CRT arm reported a decline in urinary function, whereas the IMRT arm continued to improve (mean change in EPIC urinary score = 0.5, standard deviation = 13.0, IMRT -6.0, standard deviation = 14.3, CRT, = .005). In conclusion, IMRT reduces patient-reported chronic GI and urinary toxicity with no difference in treatment efficacy at 3 years.
Journal Title: Journal of Clinical Oncology
ISSN: 0732-183X
Publisher: Unknown  
Date Published: 2022