Global epidemiology of systemic lupus erythematosus Journal Article

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Authors: Barber, M. R. W.; Drenkard, C.; Falasinnu, T.; Hoi, A.; Mak, A.; Kow, N. Y.; Svenungsson, E.; Peterson, J.; Clarke, A. E.; Ramsey-Goldman, R.
Article Title: Global epidemiology of systemic lupus erythematosus
Abstract: Systemic lupus erythematosus (SLE) is an autoimmune disease with protean manifestations that predominantly affects young women. Certain ethnic groups are more vulnerable than others to developing SLE and experience increased morbidity and mortality. Reports of the global incidence and prevalence of SLE vary widely, owing to inherent variation in population demographics, environmental exposures and socioeconomic factors. Differences in study design and case definitions also contribute to inconsistent reporting. Very little is known about the incidence of SLE in Africa and Australasia. Identifying and remediating such gaps in epidemiology is critical to understanding the global burden of SLE and improving patient outcomes. Mortality from SLE is still two to three times higher than that of the general population. Internationally, the frequent causes of death for patients with SLE include infection and cardiovascular disease. Even without new therapies, mortality can potentially be mitigated with enhanced quality of care. This Review focuses primarily on the past 5 years of global epidemiological studies and discusses the regional incidence and prevalence of SLE and top causes of mortality.
Journal Title: Nature reviews.Rheumatology
Volume: 17
Issue: 9
ISSN: 1759-4804
Publisher: . Springer Nature Limited  
Date Published: 2021
Start Page: 515
End Page: 532
Language: eng
DOI/URL:

10.1038/s41584-021-00668-1
Notes: LR: 20220406; CI: © 2021; GR: K01 AR079039/AR/NIAMS NIH HHS/United States; JID: 101500080; EIN: Nat Rev Rheumatol. 2021 Sep 1;:. PMID: 34471268; NIHMS1780632; PMCR: 2022/09/01; 2021/07/09 00:00 [accepted]; 2022/09/01 00:00 [pmc-release]; 2021/08/05 06:00 [pubmed]; 2021/09/21 06:00 [medline]; 2021/08/04 06:59 [entrez]; ppublish
LUC Authors
  1. Jonna Peterson
    14 Peterson
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