A Mathematical Model for early HBV and -HDV Kinetics during Anti-HDV Treatment. Journal Article

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Authors: Zakh, R; Churkin, A; Bietsch, W; Lachiany, M; Cotler, SJ; Ploss, A; Dahari, H; Barash, D
Article Title: A Mathematical Model for early HBV and -HDV Kinetics during Anti-HDV Treatment.
Abstract: Hepatitis delta virus (HDV) is an infectious subviral agent that can only propagate in people infected with hepatitis B virus (HBV). HDV/HBV infection is considered to be the most severe form of chronic viral hepatitis. In this contribution, a mathematical model for the interplay between HDV and HBV under anti-HDV treatment is presented. Previous models were not designed to account for the observation that HBV rises when HDV declines with HDV-specific therapy. In the simple model presented here, HDV and HBV kinetics are coupled, giving rise to an improved viral kinetic model that simulates the early interplay of HDV and HBV during anti-HDV therapy.
Journal Title: Mathematics (Basel, Switzerland)
Publisher: Unknown  
Date Published: 2021