Vitamin D Supplementation for the Treatment of Depressive Symptoms in Women with Type 2 Diabetes: A Randomized Clinical Trial. Journal Article


Authors: Penckofer, S; Ridosh, M; Adams, W; Grzesiak, M; Woo, J; Byrn, M; Kouba, J; Sheean, P; Kordish, C; Durazo-Arvizu, R; Wallis, D; Emanuele, MA; Halaris, A
Article Title: Vitamin D Supplementation for the Treatment of Depressive Symptoms in Women with Type 2 Diabetes: A Randomized Clinical Trial.
Abstract: Aim: To determine the efficacy and safety of vitamin D supplementation in reducing depressive symptoms in women with type 2 diabetes (T2D), depression, and low vitamin D. Methods: In this double-blind randomized active comparator-controlled trial, women with significant depressive symptoms as assessed by the Center for Epidemiologic Studies Depression (CES-D) scale received weekly oral vitamin D supplementation (50,000?IU) or an active comparator (5,000?IU) for 6 months. Assessments of vitamin D, 25-hydroxyvitamin D [25 (OH) D], and depression were measured at baseline, 3 months, and 6 months. Results: A total of 129 women were randomized, from which 119 completed the study (57 in lower dose and 62 in higher dose). Participants had an average 25 (OH) D and HbA1c of 20.8?ng/mL and 7.8%, respectively, at baseline. They were diverse (48% Black) and had a mean age of 50 and T2D for about 8 years. Upon completion of vitamin D supplementation, serum 25 (OH) D levels increased with 50,000?IU (+34?ng/mL) and 5,000?IU (+10?ng/mL). There was no difference in CES-D scores by treatment dose. Overall, depressive symptoms significantly improved over time with an average CES-D decline of 12.98 points (95% CI: -15.04 to -10.93; 0.001). Among women with moderate baseline depressive symptoms, those receiving the lower dose had nominally lower depression scores at follow-up than those in the higher dose cohort. Among women with severe baseline depressive symptoms, the improvement in follow-up depression scores was the same regardless of dose. Conclusions: There was no difference in the dosing effect of vitamin D supplementation for the treatment of depressive symptoms in women with T2D who present with significant symptoms and low vitamin D. Regardless of the dose, participants' mood improved over time. Further study of vitamin D to target depressive symptoms in comorbid populations is needed.
Journal Title: Journal of diabetes research
Publisher: Unknown  
Date Published: 2022
LUC Authors
  1. Angelos Halaris
    35 Halaris
  2. Joanne Kouba
    5 Kouba
  3. Monique Ridosh
    13 Ridosh
  4. Mary Byrn
    8 Byrn
  5. Patricia Sheean
    32 Sheean
  6. Bill Adams
    80 Adams
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