Coronary volume to left ventricular mass ratio in patients with diabetes mellitus. Journal Article

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Authors: Kuneman, JH; El Mahdiui, M; van Rosendael, AR; van den Hoogen, IJ; Patel, MR; Nørgaard, BL; Fairbairn, TA; Nieman, K; Akasaka, T; Berman, DS; Hurwitz Koweek, LM; Pontone, G; Kawasaki, T; Rønnow Sand, NP; Jensen, JM; Amano, T; Poon, M; Øvrehus, KA; Sonck, J; Rabbat, MG; De Bruyne, B; Rogers, C; Matsuo, H; Bax, JJ; Leipsic, JA; Knuuti, J
Article Title: Coronary volume to left ventricular mass ratio in patients with diabetes mellitus.
Abstract: BACKGROUND: Diabetes mellitus is a major risk factor for coronary artery disease (CAD) and may provoke structural and functional changes in coronary vasculature. The coronary volume to left ventricular mass (V/M) ratio is a new anatomical parameter capable of revealing a potential physiological imbalance between coronary vasculature and myocardial mass. The aim of this study was to examine the V/M derived from coronary computed tomography angiography (CCTA) in patients with diabetes. METHODS: Patients with clinically suspected CAD enrolled in the ADVANCE (Assessing Diagnostic Value of Non-invasive FFRCT in Coronary Care) registry and known diabetic status were included. Coronary artery volume and left ventricular myocardial mass were analyzed from CCTA and the V/M ratio was calculated and compared between patients with and without diabetes. RESULTS: Of the 3053 patients (age 66 ?± ?10 years; 66% male) with known diabetic status, diabetes was present in 21.9%. Coronary volume was lower in patients with diabetes compared to those without diabetes (2850 ?± ?940 ?mm vs. 3040 ?± ?970 ?mm, p ? ?0.0001), whereas the myocardial mass was comparable between the 2 groups (122 ?± ?33 ?g vs. 122 ?± ?32 ?g, p ?= ?0.70). The V/M ratio was significantly lower in patients with diabetes (23.9 ?± ?6.8 ?mm/g vs. 25.7 ?± ?7.5 ?mm/g, p ? ?0.0001). Among subjects with obstructive CAD (n ?= ?2191, 24.0% diabetics) and non-obstructive CAD (16.7% diabetics), the V/M ratio was significantly lower in patients with diabetes compared to those without (23.4 ?± ?6.7 ?mm/g vs. 25.0 ?± ?7.3 ?mm/g, p ? ?0.0001 and 25.6 ?± ?6.9 ?mm/g vs. 27.3 ?± ?7.6 ?mm/g, respectively, p ?= ?0.006). CONCLUSION: The V/M ratio was significantly lower in patients with diabetes compared to non-diabetics, even after correcting for obstructive coronary stenosis. The clinical value of the reduced V/M ratio in diabetic patients needs further investigation.
Journal Title: Journal of cardiovascular computed tomography
ISSN: 1876-861X; 1876-861X
Publisher: Unknown  
Date Published: 2022