Early HBV RNA kinetics under NA treatment may reveal new insights into HBV RNA dynamics and NA mode of action-more detailed kinetic studies are needed. Journal Article

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Authors: Dahari, H; Shlomai, A; Cotler, SJ
Article Title: Early HBV RNA kinetics under NA treatment may reveal new insights into HBV RNA dynamics and NA mode of action-more detailed kinetic studies are needed.
Abstract: We read with interest the study of Goncalves and colleagues , presenting a multi-compartmental mathematical model to explain the observed decline of both serum HBV DNA (sDNA) and HBV RNA (sRNA) in chronic HBV-infected patients treated with the core-protein assembly modulator RG7907 for 4 weeks. The authors used their model to predict early sRNA kinetics in chronic HBV-infected patients during nucleosidic analogue (NA) therapy.
Journal Title: Journal of viral hepatitis
ISSN: 1365-2893; 1352-0504
Publisher: Unknown  
Date Published: 2021