Authors: | Dahari, H; Shlomai, A; Cotler, SJ |
Article Title: | Early HBV RNA kinetics under NA treatment may reveal new insights into HBV RNA dynamics and NA mode of action-more detailed kinetic studies are needed. |
Abstract: | We read with interest the study of Goncalves and colleagues , presenting a multi-compartmental mathematical model to explain the observed decline of both serum HBV DNA (sDNA) and HBV RNA (sRNA) in chronic HBV-infected patients treated with the core-protein assembly modulator RG7907 for 4 weeks. The authors used their model to predict early sRNA kinetics in chronic HBV-infected patients during nucleosidic analogue (NA) therapy. |
Journal Title: | Journal of viral hepatitis |
ISSN: | 1365-2893; 1352-0504 |
Publisher: | Unknown |
Date Published: | 2021 |