Cytokine Profiles and Severity of Influenza Infection in Transplant Recipients. Journal Article


Authors: L'Huillier, AG; Ferreira, VH; Hirzel, C; Cordero, E; Limaye, AP; Reid, G; Englund, J; Blumberg, E; Kumar, D; Humar, A
Article Title: Cytokine Profiles and Severity of Influenza Infection in Transplant Recipients.
Abstract: Influenza is responsible for significant morbidity after transplantation. We evaluated Th1/Th2 cytokines and IL-10 levels during influenza infection in the post-transplant setting. Sera from 277 transplant recipients were analyzed at influenza diagnosis and 28 days later for IFN-?, IL-4, IL-13 and IL-10. IL-13 levels were associated with protection against pneumonia and ICU admission, whereas the IFN-?/IL-13 ratio and IL-10 levels were associated with an increased risk of pneumonia and ICU admission. This association was independent of viral load. A skewing of immune responses towards Th2 in transplant patients appears to confer protection from severe influenza infection, independently of viral load.
Journal Title: The Journal of infectious diseases
ISSN: 1537-6613; 0022-1899
Publisher: Unknown  
Date Published: 2018
LUC Authors
  1. Gail Reid
    18 Reid
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