Racial disparity in survival from estrogen and progesterone receptor-positive breast cancer: implications for reducing breast cancer mortality disparities Journal Article

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Authors: Rauscher, G. H.; Silva, A; Pauls, H.; Frasor, J.; Bonini, M. G.; Hoskins, K
Article Title: Racial disparity in survival from estrogen and progesterone receptor-positive breast cancer: implications for reducing breast cancer mortality disparities
Abstract: INTRODUCTION: Non-Latina black breast cancer patients experience a shorter survival from breast cancer than their non-Latina white counterparts. We compared breast cancer-specific survival for the subset of black and white patients with estrogen and/or progesterone receptor-positive tumors that are generally targeted with endocrine therapy. METHODS: Using data collected from a population-based cohort of breast cancer patients from Chicago, IL, Kaplan-Meier survival curves and hazard functions were generated and proportional hazards models were estimated to determine the black/white disparity in time to death from breast cancer while adjusting for age at diagnosis, patient characteristics, treatment-related variables, and tumor grade and stage. RESULTS: In regression models, hazard of breast cancer death among ER/PR-positive patients was at least 4 times higher for black than for white patients in all models tested. Notably, even after adjusting for stage at diagnosis, tumor grade, and treatment variables (including initiation of systemic adjuvant therapies), the hazard ratio for death from ER/PR-positive breast cancer between black and white women was 4.39 (95% CI 1.76, 10.9, p = 0.001). CONCLUSIONS: We observed a racial disparity in breast cancer survival for patients diagnosed with ER/PR-positive tumors that did not appear to be due to differences in tumor stage, grade, or therapy initiation in black patients, suggesting that there may be racial differences in the molecular characteristics of hormone receptor-positive tumors, such that ER/PR-positive tumors in black patients may be less responsive to standard treatments.
Journal Title: Breast cancer research and treatment
Volume: 163
Issue: 2
ISSN: 1573-7217
Publisher: Unknown  
Date Published: 2017
Start Page: 321
End Page: 330
Language: eng
DOI/URL:

10.1007/s10549-017-4166-z
Notes: LR: 20181113; GR: P50 CA106743/CA/NCI NIH HHS/United States; JID: 8111104; 0 (Biomarkers, Tumor); 0 (Receptors, Estrogen); 0 (Receptors, Progesterone); CIN: Breast Cancer Res Treat. 2017 Jul;164(1):247. PMID: 28396965; NIHMS856807; OTO: NOTNLM; 2017/01/05 00:00 [received]; 2017/02/15 00:00 [accepted]; 2017/03/03 06:00 [pubmed]; 2018/02/20 06:00 [medline]; 2017/03/03 06:00 [entrez]; ppublish