Reproducibility and reliability of anti-3-[¹8F]FACBC uptake measurements in background structures and malignant lesions on follow-up PET-CT in prostate carcinoma: an exploratory analysis. Journal Article

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Authors: Odewole, OA; Oyenuga, OA; Tade, F; Savir-Baruch, B; Nieh, PT; Master, V; Chen, Z; Wang, X; Jani, AB; Bellamy, LM; Halkar, RK; Goodman, MM; Schuster, DM
Article Title: Reproducibility and reliability of anti-3-[¹8F]FACBC uptake measurements in background structures and malignant lesions on follow-up PET-CT in prostate carcinoma: an exploratory analysis.
Abstract: PURPOSE: The aim of this study is to examine the reproducibility of anti-1-amino-3-[(18)F]fluorocyclobutane-1-carboxylic acid (anti-3-[(18)F]FACBC) quantitative measurements in key background structures and untreated malignant lesions. PROCEDURES: Retrospective review of 14 patients who underwent follow-up anti-3-[(18)F]FACBC positron emission tomography-X-ray computed tomography (PET-CT) for prostate carcinoma recurrence. Standard uptake values (SUV) were measured in both original and follow-up scans in key background structures and untreated malignant lesions. Absolute and percent mean difference in SUV between scans and interclass correlation coefficients (ICC) were also computed. RESULTS: Mean (±SD, range) scan interval was 17.4 months (±7.1, 4-29). %Mean difference in SUVmean was 20 % in background structures with low absolute differences. ICCs were >0.6 except for early-phase blood pool (ICC?=?0.4). SUVmax in malignant lesions without interim therapy increased or remained stable over time. CONCLUSIONS: Despite variable time interval between scans, FACBC PET-CT demonstrates acceptable reproducibility in key background structures. Untreated malignant lesions showed stable or increased uptake over time. A formal test-retest study is planned.
Journal Title: Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging
Publisher: Unknown  
Date Published: 2015