Risk factors for infection and evaluation of Sepsis-3 in patients with trauma. Journal Article

Authors: Eguia, E; Cobb, AN; Baker, MS; Joyce, C; Gilbert, E; Gonzalez, R; Afshar, M; Churpek, MM
Article Title: Risk factors for infection and evaluation of Sepsis-3 in patients with trauma.
Abstract: BACKGROUND: We aim to examine the risk factors associated with infection in trauma patients and the Sepsis-3 definition. METHODS: This was a retrospective cohort study of adult trauma patients admitted to a Level I trauma center between January 2014 and January 2016. RESULTS: A total of 1499 trauma patients met inclusion criteria and 15% (n?=?232) had an infection. Only 19.8% (n?=?46) of infected patients met criteria for Sepsis-3, with the majority (43%) of infected cases having a Sequential Organ Failure Assessment (SOFA) score greater on admission compared to the time of suspected infection. In-hospital death was 7% vs 9% (p?=?0.65) between Sepsis-3 and infected patients, respectively. Risk factors associated with infection were female sex, admission SOFA score, Elixhauser score, and severe injury (P?0.05). CONCLUSION: Patients with trauma often arrive with organ dysfunction, which adds complexity and inaccuracy to the operational definition of Sepsis-3 using changes in SOFA scores. Injury severity score, comorbidities, SOFA score, and sex are risk factors associated with developing an infection after trauma.
Journal Title: American Journal of Surgery
ISSN: 1879-1883; 0002-9610
Publisher: Elsevier Inc  
Date Published: 2019
LUC Authors
  1. Emily Gilbert
    11 Gilbert
  2. Majid Afshar
    69 Afshar
  3. Cara Joyce
    201 Joyce
  4. Marshall Baker
    66 Baker
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