Intrapatient variability in tacrolimus trough levels after solid organ transplantation varies at different postoperative time periods. Journal Article

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Authors: Gueta, I; Markovits, N; Yarden-Bilavsky, H; Raichlin, E; Freimark, D; Lavee, J; Loebstein, R; Peled, Y
Article Title: Intrapatient variability in tacrolimus trough levels after solid organ transplantation varies at different postoperative time periods.
Abstract: We thank Lemaitre et al for their letter regarding our manuscript describing the association between intrapatient variability (IPV) of tacrolimus (TAC) trough levels and long-term outcomes in heart transplant (HTx) patients. Indeed, in our study we found that high TAC through level variability at 3-12 months post-HTx was associated with higher rates of graft rejection at odds ratio (OR) of 8.52. However, we wish to clarify that due to the wide 95% confidence interval (1.63-44.53), the minimum odds might also be 1.63 and hence prefer not to define the risk of high TAC through level variability as "tremendous" . This article is protected by copyright. All rights reserved.
Journal Title: American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
ISSN: 1600-6143; 1600-6135
Publisher: Unknown  
Date Published: 2018
LUC Authors
  1. Eugenia Raichlin
    22 Raichlin
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