An evaluation of nutritional and vasoactive stimulants as risk factors for gastroschisis: a pilot study Journal Article

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Authors: Goodman, J. R.; Peck, J. D.; Landmann, A.; Williams, M.; Elimian, A.
Article Title: An evaluation of nutritional and vasoactive stimulants as risk factors for gastroschisis: a pilot study
Abstract: OBJECTIVE: The objective of this study is to evaluate poor maternal nutrition, environmental exposures and vasoactive stimulants as potential risk factors for gastroschisis. METHODS: A case-control study was conducted among singleton pregnancies diagnosed in a tertiary teaching hospital in a 22-month period. Cases of gastroschisis were matched to controls at the time of diagnosis by race and maternal age. Demographics, periconceptual exposures, nutritional biomarkers, and illicit drug hair analysis were evaluated. Analyses were performed using conditional logistic regression. RESULTS: Thirty gastroschisis cases and 76 controls were studied with no associations observed for illicit drug use or serum levels of ferritin, iron, B6, B12, folate, or zinc. Neither prescription medication nor over the counter mediation use differed between cases and controls. Following adjustment for insurance, education, low BMI, and nulliparity, mothers of gastroschisis cases had an increased odds of alcohol use 1 month prior and/or during early pregnancy compared with controls, with adjusted odds ratio (OR) 3.19 (95% CI 1.01-11.61). CONCLUSIONS: Our findings suggest that further investigation of vasoactive stimulants such as alcohol is warranted in the search to identify risk factors for gastroschisis.
Journal Title: The journal of maternal-fetal neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians
ISSN: 1476-4954; 1476-4954
Publisher: Unknown  
Journal Place: England
Date Published: 2018
Start Page: 1
End Page: 8
Language: eng
DOI/URL:

10.1080/14767058.2018.1433657
Notes: LR: 20180208; JID: 101136916; OTO: NOTNLM; 2018/02/09 06:00 [entrez]; 2018/02/09 06:00 [pubmed]; 2018/02/09 06:00 [medline]; aheadofprint; SO: J Matern Fetal Neonatal Med. 2018 Feb 7:1-8. doi: 10.1080/14767058.2018.1433657.