Association of depression with antihypertensive medication adherence in older adults: cross-sectional and longitudinal findings from CoSMO Journal Article

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Authors: Krousel-Wood, M; Islam, T.; Muntner, P; Holt, E.; Joyce, C; Morisky, D. E.; Webber, L. S.; Frohlich, E. D.
Article Title: Association of depression with antihypertensive medication adherence in older adults: cross-sectional and longitudinal findings from CoSMO
Abstract: BACKGROUND: Little is known about the associations between depressive symptoms, social support and antihypertensive medication adherence in older adults. PURPOSE: We evaluated the cross-sectional and longitudinal associations between depressive symptoms, social support and antihypertensive medication adherence in a large cohort of older adults. METHODS: A cohort of 2,180 older adults with hypertension was administered questionnaires, which included the Center for Epidemiologic Studies-Depression Scale, the Medical Outcomes Study Social Support Index, and the hypertension-specific Morisky Medication Adherence Scale at baseline and 1 year later. RESULTS: Overall, 14.1% of participants had low medication adherence, 13.0% had depressive symptoms, and 33.9% had low social support. After multivariable adjustment, the odds ratios that participants with depressive symptoms and low social support would have low medication adherence were 1.96 (95% confidence interval (CI) 1.43, 2.70) and 1.27 (95% CI 0.98, 1.65), respectively, at baseline and 1.87 (95% CI 1.32, 2.66) and 1.30 (95% CI 0.98, 1.72), respectively, at 1 year follow-up. CONCLUSION: Depressive symptoms may be an important modifiable barrier to antihypertensive medication adherence in older adults.
Journal Title: Annals of Behavioral Medicine : A Publication of the Society of Behavioral Medicine
Volume: 40
Issue: 3
ISSN: 1532-4796; 0883-6612
Publisher: Unknown  
Journal Place: United States
Date Published: 2010
Start Page: 248
End Page: 257
Language: eng
DOI/URL:

10.1007/s12160-010-9217-1
Notes: LR: 20161025; GR: R01 AG022536/AG/NIA NIH HHS/United States; GR: R01 AG022536-04/AG/NIA NIH HHS/United States; JID: 8510246; 0 (Antihypertensive Agents); NIHMS291208; OID: NLM: NIHMS291208; OID: NLM: PMC3109732; ppublish